J
Janice Cheng
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 4
Citations - 1756
Janice Cheng is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: CEBPA & Germline mutation. The author has an hindex of 3, co-authored 4 publications receiving 1548 citations.
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Journal ArticleDOI
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
Jay P. Patel,Mithat Gonen,Maria E. Figueroa,Hugo Fernandez,Zhuoxin Sun,Janis Racevskis,Pieter Van Vlierberghe,Igor Dolgalev,Sabrena Thomas,Olga Aminova,Kety Huberman,Janice Cheng,Agnes Viale,Nicholas D. Socci,Adriana Heguy,Athena M. Cherry,Gail H. Vance,Rodney R. Higgins,Rhett P. Ketterling,Robert E. Gallagher,Mark R. Litzow,Marcel R.M. van den Brink,Hillard M. Lazarus,Jacob M. Rowe,Selina M. Luger,Adolfo A. Ferrando,Elisabeth Paietta,Martin S. Tallman,Ari Melnick,Omar Abdel-Wahab,Ross L. Levine +30 more
TL;DR: Genetic predictors of outcome that improved risk stratification among patients with AML, independently of age, white-cell count, induction dose, and post-remission therapy, are identified and the significance of these predictors in an independent cohort is validated.
Journal ArticleDOI
Detection of Mutations in Myeloid Malignancies through Paired-Sample Analysis of Microdroplet-PCR Deep Sequencing Data
Donavan T. Cheng,Janice Cheng,Talia Mitchell,Aijazuddin Syed,Ahmet Zehir,Nana Mensah,Alifya Oultache,Khedoudja Nafa,Ross L. Levine,Maria E. Arcila,Michael F. Berger,Cyrus V. Hedvat +11 more
TL;DR: A paired-sample analysis pipeline capable of robust identification of mutations from microdroplet-PCR sequencing data with high sensitivity and specificity is developed.
Journal ArticleDOI
High-Throughput Mutational Profiling In AML: Mutational Analysis of the ECOG E1900 Trial
Jay P. Patel,Omar Abdel-Wahab,Mithat Gonen,Maria E. Figueroa,Hugo F. Fernandez,Zhuoxin Sun,Janis Racevskis,Pieter Van lierberghe,Igor Dolgalev,Janice Cheng,Agnes Viale,Nicholas D. Socci,Adriana Heguy,Rhett P. Ketterling,Robert E. Gallagher,Mark R. Litzow,Jacob M. Rowe,Adolfo A. Ferrando,Elisabeth Paietta,Martin S. Tallman,Ari Melnick,Ross L. Levine +21 more
TL;DR: Full-length DNA resequencing of FLT3, NPM1, CEBPA, H/K/NRAS, KIT, WT1, TET2, ASXL1, IDH1/2, TP53, RUNX1, PTEN, and PHF6 in pre-treatment genomic DNA from 398 patients with de novo AML demonstrates that increased intensity induction chemotherapy can improve outcomes in genetically defined poor risk AML subsets.
Detection of Mutations in Myeloid Malignancies through Paired-Sample Analysis of MicrodropletePolymerase Chain Reaction Deep Sequencing Data
Donavan T. Cheng,Janice Cheng,Talia Mitchell,Aijazuddin Syed,Ahmet Zehir,Nana Yaa,T. Mensah,Alifya Oultache,Khedoudja Nafa,Ross L. Levine,Maria E. Arcila,Michael F. Berger,Cyrus V. Hedvat +12 more
TL;DR: A paired-sample analysis pipeline capable of robust identification of mutations from microdroplet-PCR sequencing data with high sensitivity and specificity is developed.