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Alison L. Allan
Researcher at University of Western Ontario
Publications - 77
Citations - 4572
Alison L. Allan is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Cancer & Metastasis. The author has an hindex of 31, co-authored 75 publications receiving 4003 citations. Previous affiliations of Alison L. Allan include London Health Sciences Centre & Lawson Health Research Institute.
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Journal ArticleDOI
High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability.
Alysha K. Croker,David Goodale,Jenny E. Chu,Carl O. Postenka,Benjamin D. Hedley,David A. Hess,Alison L. Allan +6 more
TL;DR: The hypothesis that stem‐like cells play a key role in metastatic behaviour in breast cancer metastasis is tested and novel results suggest that stem-cell‐like ALDHhiCD44+CD24− and ALDHHICD44-CD133+ cells may be important mediators of breast cancer tumours metastasis.
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The Role of Human Aldehyde Dehydrogenase in Normal and Cancer Stem Cells
TL;DR: A comprehensive review discusses the role that ALDH plays in normal stem cells and CSCs, with focus on ALDH1 and ALDH3A1.
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Inhibition of aldehyde dehydrogenase (ALDH) activity reduces chemotherapy and radiation resistance of stem-like ALDHhiCD44+ human breast cancer cells
TL;DR: The novel findings indicate that ALDHhiCD44+ breast cancer cells contribute to both chemotherapy and radiation resistance and suggest a much broader role for ALDH in treatment response than previously reported.
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Cancer stem cells: implications for the progression and treatment of metastatic disease.
Alysha K. Croker,Alison L. Allan +1 more
TL;DR: The cancer stem cell hypothesis is supported and theTherapeutic implications and future directions are outlined.
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Circulating Tumor Cell Analysis: Technical and Statistical Considerations for Application to the Clinic
TL;DR: This review will focus on the important technical and statistical considerations that must be taken into account when designing and implementing CTC assays, as well as the subsequent interpretation of these results for the purposes of clinical decision making.