A
Alton Meister
Researcher at National Institutes of Health
Publications - 195
Citations - 15525
Alton Meister is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Glutathione & Amino acid. The author has an hindex of 70, co-authored 195 publications receiving 15267 citations. Previous affiliations of Alton Meister include Virginia Tech.
Papers
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Journal ArticleDOI
Glutathione: interorgan translocation, turnover, and metabolism.
Owen W. Griffith,Alton Meister +1 more
TL;DR: The present and earlier findings lead to a tentative scheme for the metabolism and translocation of glutathione, gamma-glutamyl amino acids, and related compounds.
Journal ArticleDOI
The γ-Glutamyl Cycle: A Possible Transport System for Amino Acids
Marian Orlowski,Alton Meister +1 more
TL;DR: Evidence is presented that rat kidney contains enzymes that catalyze the synthesis and utilization of glutathione and these reactions, which involve the uptake and release of amino acids from γ-glutamyl linkage, constitute a cyclical process, which has properties that fulfill the requirements of an amino acid transport system.
Journal ArticleDOI
Glutathione deficiency leads to mitochondrial damage in brain
TL;DR: This paper showed that buthionine sulfoximine, a selective inhibitor of gamma-glutamylcysteine synthetase, led to markedly decreased cerebral cortex glutathione levels and striking enlargement and degeneration of the mitochondria.
Book ChapterDOI
Gamma-glutamyl transpeptidase.
TL;DR: This chapter presents a procedure for the preparation of γ- glutamyl transpeptidase, the most widely used substrate is L-y-glutamyl-p-nitroanilide, and various methods of solubilization are employed including the treatment of the particulate enzyme with detergents, organic solvents, and proteinases.