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Showing papers by "Amal H. Aly published in 2009"

Journal Article•
Bioactive secondary metabolites from the endophytic fungus Chaetomium sp. isolated from Salvia officinalis growing in Morocco

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Abdessamad Debbab1, Amal H. Aly1, RuAngelie Edrada-Ebel2, Werner E.G. Müller3, Mahjouba Mosaddak, A. Hakiki, Rainer Ebel2, Peter Proksch1 •
University of Düsseldorf1, Strathclyde Institute of Pharmacy and Biomedical Sciences2, University of Mainz3
01 Jan 2009-Biotechnologie, Agronomie, Société et Environnement
TL;DR: In this paper, the structure and cytotoxicite of metabolites secondaires produced by le champignon endophytique Chaetomium sp. isole de Salvia officinalis in Beni-Mellal, Maroc, Africa, are investigated.
Abstract: Metabolites secondaires bioactifs du champignon endophytique Chaetomium sp. isole de Salvia officinalis qui pousse au Maroc. Cette etude rapporte l'elucidation de la structure et de la cytotoxicite des metabolites secondaires produits par le champignon endophytique Chaetomium sp. isole de Salvia officinalis qui pousse au Maroc. Cette plante collectee dans les montagnes de Beni-Mellal au Maroc appartient a la famille des Lamiaceae et est nommee au Maroc par le nom vernaculaire “Salmia”. Le champignon endophytique Chaetomium sp. a ete isole des tissus de la tige de cette plante. Ce champignon a ete identifie par PCR. L'extrait brut du champignon isole est tres actif sur les cellules cancereuses L5178Y du lymphome de la souris. L'investigation chimique des metabolites secondaires a montre que le cochliodinol est le compose majoritaire, a cote de l'isocochliodinol. Les structures des composes isoles ont ete determinees par des analyses spectroscopiques, a savoir la RMN (1H, 13C, COSY et HMBC) et la spectrometrie de masse en utilisant le ESI (Electron Spray Ionisation) comme source.

57 citations

Journal Article•DOI•
A new tetrahydrofuran derivative from the endophytic fungus Chaetomium sp. isolated from Otanthus maritimus.

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Amal H. Aly1, Abdessamad Debbab1, RuAngelie Edrada-Ebel2, Victor Wray, Werner E.G. Müller3, Wenhan Lin, Rainer Ebel4, Peter Proksch1 •
University of Düsseldorf1, University of Strathclyde2, University of Mainz3, Strathclyde Institute of Pharmacy and Biomedical Sciences4
01 Jun 2009-Zeitschrift für Naturforschung C
TL;DR: A hitherto unidentified endophytic strain of the genus Chaetomium, isolated from the medicinal plant Otanthus maritimus, yielded a new tetrahydrofuran derivative, aureonitolic acid, which exhibited considerable cytotoxic activity when tested in vitro against L5178Y mouse lymphoma cells.
Abstract: A hitherto unidentified endophytic strain of the genus Chaetomium, isolated from the medicinal plant Otanthus maritimus, yielded a new tetrahydrofuran derivative, aureonitolic acid (1), along with 5 known natural products, 2-6. The structure of 1 was determined by extensive spectroscopic analysis and comparison with reported data. Extracts of the fungus, grown either in liquid culture or on solid rice media, exhibited considerable cytotoxic activity when tested in vitro against L5178Y mouse lymphoma cells. Compounds 2 and 6 showed significant growth inhibition against L5178Y cells with EC50 values of 7.0 and 2.7 microg/mL, respectively, whereas 1 was inactive.

8 citations