R
RuAngelie Edrada-Ebel
Researcher at Strathclyde Institute of Pharmacy and Biomedical Sciences
Publications - 140
Citations - 6825
RuAngelie Edrada-Ebel is an academic researcher from Strathclyde Institute of Pharmacy and Biomedical Sciences. The author has contributed to research in topics: Streptomyces & Plant use of endophytic fungi in defense. The author has an hindex of 37, co-authored 134 publications receiving 5642 citations. Previous affiliations of RuAngelie Edrada-Ebel include University of Strathclyde & Rothamsted Research.
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The re-emergence of natural products for drug discovery in the genomics era
TL;DR: This work reviews strategies for natural product screening that harness the recent technical advances that have reduced technical barriers and assess the use of genomic and metabolomic approaches to augment traditional methods of studying natural products.
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Effect of the environment on the secondary metabolic profile of Tithonia diversifolia : a model for environmental metabolomics of plants
TL;DR: The environment-metabolism relationship for T. diversifolia is highlighted and the combined analytical approach to obtain reliable data that contributed to a holistic understanding of the influence of abiotic environmental factors on the production of metabolites in various plant parts is highlighted.
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Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense.
Amal H. Aly,RuAngelie Edrada-Ebel,Ine Dewi Indriani,Victor Wray,Werner E G Müller,Frank Totzke,Ute Zirrgiebel,Christoph Schächtele,Michael H.G. Kubbutat,Wenhan Lin,Peter Proksch,Rainer Ebel +11 more
TL;DR: From the Egyptian medicinal plant Polygonum senegalense the fungal endophyte Alternaria sp.
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Fumarate induces redox-dependent senescence by modifying glutathione metabolism
Liang Zheng,Simone Cardaci,Livnat Jerby,Elaine D. MacKenzie,Marco Sciacovelli,T. Isaac Johnson,Edoardo Gaude,Ayala King,Joshua D.G. Leach,RuAngelie Edrada-Ebel,Ann Hedley,Nicholas A. Morrice,Galbriela Kalna,Karen Blyth,Eytan Ruppin,Christian Frezza,Eyal Gottlieb +16 more
TL;DR: The ablation of p21, a key mediator of senescence, in Fh1-deficient mice resulted in the transformation of benign renal cysts into a hyperplastic lesion, suggesting that fumarate-inducedsenescence needs to be bypassed for the initiation of renal cancers.
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Bioactive metabolites from the endophytic fungus Ampelomyces sp. isolated from the medicinal plant Urospermum picroides
Amal H. Aly,RuAngelie Edrada-Ebel,Victor Wray,Werner E.G. Müller,Svitlana Kozytska,Ute Hentschel,Peter Proksch,Rainer Ebel +7 more
TL;DR: Extracts of cultures grown in liquid or on solid rice media of the fungal endophyte Ampelomyces sp.