Amarendra B. Mikkilineni

TL;DR: In this paper, the authors present compounds of the formula "STR1" and pharmaceutically acceptable salts thereof, which are beta-three adrenergic receptor agonists and are useful in the treatment of diabetes, obesity and gastrointestinal diseases.

TL;DR: The present invention is directed to novel taxol derivatives useful as anti-tumor agents and pharmaceutical formulations and methods of treating mammalian tumors with the compounds of this invention as discussed by the authors.

TL;DR: In this article, the authors describe CB-1 inverse agonists according to Formula (I) and (Ia), pharmaceutical compositions comprising at least one compound according to formula (I), and optionally one or more additional therapeutic agents.

TL;DR: Synthesis and biological evaluation of novel taxol derivatives having a phosphonoxyphenylpropionate ester group at the 2′-position or at the 7-position of taxol are described, found to have much improved water solubility and both were found to generate taxol upon exposure to alkaline phosphatase.

TL;DR: Three new phosphate derivatives of paclitaxel-2′-ethylcarbonate 4a, 4b, and 4c, have been synthesized and evaluated for in vivo antitumor activity and two derivatives were found to exhibit in vivo anticancer activity comparable to pac litaxel in the M109 murine tumor model.