Dynamic combinatorial chemistry.

Recent applications of the Suzuki–Miyaura cross-coupling reaction in organic synthesis

Isolation and synthesis of biologically active carbazole alkaloids

Sonochemistry is the use of ultrasound to enhance or alter chemical reactions. Sonochemistry in the true sense of the term occurs when ultrasound induces “true” chemical effects on the reaction system, such as forming free radicals which accelerate the reaction. However, ultrasound may have other mechanical effects on the reaction, such as increasing the surface area between the reactants, accelerating dissolution, and/or renewing the surface of a solid reactant or catalyst. This comprehensive review summarizes several topics of study in the sonochemical literature, including bubble dynamics, factors affecting cavitation, the effects of ultrasound on a variety of chemical systems, modeling of kinetic and mass-transfer effects, the methods used to produce ultrasound, proposed cavitation reactors, and the problems of scaleup. The objective of this paper is to present a critical review of information available in the literature so as to facilitate and inspire future research in the field of sonochemistry.

Sonochemistry: Science and Engineering

Natural products to drugs: natural product derived compounds in clinical trials

Esperamicins, a novel class of potent antitumor antibiotics. 3. Structures of esperamicins A1, A2, and A1b

Esperamicins, a novel class of potent antitumor antibiotics. 2. Structure of esperamicin X

Isolation and structure of rebeccamycin - a new antitumor antibiotic from nocardia aerocoligenes

Kedarcidin, a new chromoprotein antitumor antibiotic : structure elucidation of kedarcidin chromophore

The present invention is directed to novel taxol derivatives useful as anti-tumor agents. Also provided by this invention is pharmaceutical formulations and methods of treating mammalian tumors with the compounds of this invention.

Phosphonooxy and carbonate derivatives of taxol

Terrence W. Doyle

Papers

Esperamicins, a novel class of potent antitumor antibiotics. 3. Structures of esperamicins A1, A2, and A1b

Esperamicins, a novel class of potent antitumor antibiotics. 2. Structure of esperamicin X

Isolation and structure of rebeccamycin - a new antitumor antibiotic from nocardia aerocoligenes

Kedarcidin, a new chromoprotein antitumor antibiotic : structure elucidation of kedarcidin chromophore

Phosphonooxy and carbonate derivatives of taxol