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Amber D. Bowler
Researcher at Huntsman Cancer Institute
Publications - 1
Citations - 120
Amber D. Bowler is an academic researcher from Huntsman Cancer Institute. The author has contributed to research in topics: Tyrosine-kinase inhibitor & Ponatinib. The author has an hindex of 1, co-authored 1 publications receiving 55 citations.
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Combining the Allosteric Inhibitor Asciminib with Ponatinib Suppresses Emergence of and Restores Efficacy against Highly Resistant BCR-ABL1 Mutants
Christopher A. Eide,Christopher A. Eide,Matthew S. Zabriskie,Samantha L. Savage Stevens,Orlando Antelope,Nadeem A. Vellore,Hein Than,Anna Reister Schultz,Phillip M. Clair,Amber D. Bowler,Anthony D. Pomicter,Dongqing Yan,Anna V. Senina,Wang Qiang,Wang Qiang,Todd W. Kelley,Philippe Szankasi,Michael Heinrich,Jeffrey W. Tyner,Delphine Rea,Jean Michel Cayuela,Dong-Wook Kim,Cristina E. Tognon,Cristina E. Tognon,Thomas O'Hare,Thomas O'Hare,Brian J. Druker,Brian J. Druker,Michael W. Deininger,Michael W. Deininger +29 more
TL;DR: It is demonstrated that combining asciminib with ATP site TKIs enhances target inhibition and suppression of resistant outgrowth in Ph+ clinical isolates and cell lines and restores ponatinib's effectiveness against currently untreatable compound mutants at clinically achievable concentrations.