Amit K. Gupta

TL;DR: In the presence of normal LV ejection fraction, a midsystolic shift in the pressure-stress relationship protects cardiomyocytes against excessive late systolic stress (despite pressure augmentation associated with wave reflections), a coupling mechanism that may be altered in various disease states.

TL;DR: Different arterial properties have selective effects on time-resolved ejection-phase myocardial wall stress, which are not apparent from single-time point measurements and may relate to the differential susceptibility of women to heart failure.

TL;DR: In this article, the authors used nonlinear regression to analyze a selected reference subsample (n=612) with normal weight (body mass index 18 to 25 kg/m(2)), waist circumference, and metabolic parameters, and found that the adverse effects of obesity on arterial load and ventricular stiffening were clearly demonstrated only after appropriate indexation to account for the expected normal relationship to body size.

TL;DR: Hemodynamic load provoked by isometric exercise strongly predicts LVMI in hypertension, suggesting that provoked testing captures important arterial properties that are not apparent at rest and is advantageous to assess dynamic arterial load in hypertension.

TL;DR: Prosthesis-patient mismatch results in high gradients and adverse patient outcomes, and the effective orifice area (EOAi) index, dividing EOA by body surface area (BSA), is a measure of the mismatch.