https://zenodo.org/record/1004771/files/Cushnie%20et%20al%20%282014%29%20post-peer%20reviewed%20version.pdf

Alkaloids: an overview of their antibacterial, antibiotic-enhancing and antivirulence activities.

1,3,4-Thiadiazole: Synthesis, Reactions, and Applications in Medicinal, Agricultural, and Materials Chemistry

Recent advances of pyrazole-containing derivatives as anti-tubercular agents.

Many compounds containing a five-membered heterocyclic ring display exceptional chemical properties and versatile biological activities. In this Minireview, thiadiazoles are summarized according to their therapeutic potential, highlighting the versatility of this scaffold in medicinal chemistry. The unique properties of thiadiazoles are also discussed in relation to their potential effect on activity. Thiadiazole is a bioisostere of pyrimidine and oxadiazole, and given the prevalence of pyrimidine in nature it is unsurprising that thiadiazoles exhibit significant therapeutic potential. The sulfur atom of the thiadiazole imparts improved liposolubility, and the mesoionic nature of thiadiazoles makes these compounds better able to cross cellular membranes. By summarizing the thiadiazole-containing compounds reported in recent decades, we aim to give a brief introduction to their synthesis and diverse biological activities, such as anti-inflammatory, anticancer, antibacterial, antifungal, antiviral, antiparasitic, anticonvulsant, anticoagulant, antidiabetic, and to show the significant utility of the thiadiazole scaffolds in medicinal chemistry.

Thiadiazole-a promising structure in medicinal chemistry.

Imidazoles have occupied a unique position in heterocyclic chemistry, and its derivatives have attracted considerable interests in recent years for their versatile properties in chemistry and pharmacology. Imidazole is nitrogen-containing heterocyclic ring which possesses biological and pharmaceutical importance. Thus, imidazole compounds have been an interesting source for researchers for more than a century. The imidazole ring is a constituent of several important natural products, including purine, histamine, histidine, and nucleic acid. Being a polar and ionisable aromatic compound, it improves pharmacokinetic characteristics of lead molecules and thus is used as a remedy to optimize solubility and bioavailability parameters of proposed poorly soluble lead molecules. There are several methods used for the synthesis of imidazole-containing compounds, and also their various structure reactions offer enormous scope in the field of medicinal chemistry. The imidazole derivatives possess extensive spectrum of biological activities such as antibacterial, anticancer, antitubercular, antifungal, analgesic, and anti-HIV activities. This paper aims to review the biological activities of imidazole during the past years.

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Imidazole: Having Versatile Biological Activities

Novel imidazo[2,1-b][1,3,4]thiadiazole carrying rhodanine-3-acetic acid as potential antitubercular agents

A simple, highly efficient, cost effective, and environmentally benign synthesis of the title compounds (IX) (7 examples) and related analogues (XI), (XIII) is developed using microwave technique.

Novel Imidazo[2,1-b][1,3,4]thiadiazole Carrying Rhodanine-3-acetic Acid as Potential Antitubercular Agents.

Mannich Reaction as a New Route for the Synthesis of Tetrahydro Pyrimido Benzimidazolyl Coumarins

15 Title compounds of type (IV) are prepared and tested for their anti-inflammatory activities.

Amol S. Shah

Papers

Novel imidazo[2,1-b][1,3,4]thiadiazole carrying rhodanine-3-acetic acid as potential antitubercular agents

Novel Imidazo[2,1-b][1,3,4]thiadiazole Carrying Rhodanine-3-acetic Acid as Potential Antitubercular Agents.

Mannich Reaction as a New Route for the Synthesis of Tetrahydro Pyrimido Benzimidazolyl Coumarins

Mannich Reaction as a New Route for the Synthesis of Tetrahydro Pyrimido Benzimidazolyl Coumarins.