Journal of Heterocyclic Chemistry 

About: Journal of Heterocyclic Chemistry is an academic journal. The journal publishes majorly in the area(s): Ring (chemistry) & Bicyclic molecule. It has an ISSN identifier of 0022-152X. Over the lifetime, 16312 publication(s) have been published receiving 174309 citation(s).

Biological importance of the indole nucleus in recent years: A comprehensive review

Abstract: Heterocyclic compounds are those cyclic compounds in which one or more of the ring carbons are replaced by another atom. The non-carbon atoms in such rings are referred to as ‘‘heteroatoms.’’ Such bicyclic heterocyclic compounds containing pyrrole ring with benzene ring fused to a,b-position are known as Indoles. Indole has a benzene ring and pyrrole ring sharing one double bond. It is a heterocyclic system with 10 electrons from four double bonds and the lone pair from the nitrogen atom. Indole is an important heterocyclic system because it is built into proteins in the form of amino acid tryptophan, because it is the basis of drugs like indomethacin and because it provides the skeleton of indole alkaloids—biologically active compounds from plants including strychnine and LSD. The incorporation of indole nucleus, a biologically accepted pharmacophore in medicinal compounds (Table 1), has made it versatile heterocyclic possessing wide spectrum of biological activities (Table 2). In the present study, we have made an attempt to collect biological properties of imidazole nucleus reported in the new millennium.

Synthesis of some imidazole- and pyrazole- derived chelating agents

Abstract: Procedures involving condensation of o-phenylenediamines with carboxylic acids, and reaction of bifunctional alkyl halides with bifunctional nucleophiles are described. Syntheses are reported of 2,6-bis-(2-benzimidazyl)-pyridine, 1,3-bis(2-benzimidazyl)-2-thiapropane, 1,7-bis(2-benzimidazyl)-2,6-dithiaheptane, 2-hydroxymethyl-5,6-dimethylbenzimidazole, 2-chloromethyl-5,6-dimethylbenzimidazole hydrochloride, 1,7-bis(5,6-dimethyl-2-benzimidazyl)-2,6-dithiaheptane, 3,6-bis(1-pyrazolyl)pyridazine, 2-(2-hydroxy-3-methyl–phenyl)benzimidazole, 2-(2-hydroxyphenyl)benzimidazole, 5-(2-hydroxphenyl)-3-methyl-1-phenylpyrazole, 3(5)-(2-hydroxyphenyl)-5(3)-methylpyrazole, 3(5)-(2-hydroxyphenyl)-5(3)-phenylpyrazole, and 1,3-bis((5-methylpyridyl)imino)isoindoline.

The synthesis of some substituted tetraarylporphyrins

Abstract: The synthesis of six unsymmetrically substituted tetraarylporphyrins is reported. The compounds prepared are 5-(R),10,15,20-tritolylporphyrins, where R = 2-pyridyl, 3-pyridyl, 4-acet-amido, and 2,3 or 4-hydroxyphenyl. Four new tetrasubstituted tetraarylporphyrins (5,10,15,20-tetra-(R)-porphyrin) are also reported, where R = 3-pyridyl, 4-acetylphenyl, 4-hydroxyphenyl and 4-butoxyphenyl. The proton nmr spectra of these porphyrins are presented.

Chemistry and antiviral activities of acyclonucleosides

Abstract: Article de synthese sur les acyclonucleosides derives de purine ou de pyrimidine et les acyclo-C-nucleosides

2-aminothiophenes by the gewald reaction

Abstract: The review presents the most elegant and promising set of synthetic routes for the synthesis of 2-aminothiophenes by the Gewald reaction Applications of this facile methodology to pharmaceuticals and dyestuffs have been demonstrated