Data Mining - Concepts and Techniques.

Much work has been carried out in recent years on the beneficial effect of phenolic compounds which act as natural antioxidants and help to neutralize free radicals. We analysed the antioxidant activity of the rutin (quercetin-3-rhamnosyl glucoside) using different assays including: total antioxidant activity and reducing power, hydroxyl radical scavenging assay, superoxide radical scavenging assay, 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging assay and lipid peroxidation assay which uses egg yolk as the lipid-rich source. Total antioxidant capacity was determined by the assay based on the decrease in absorbance of β-carotene by the sample. Rutin exhibited strong DPPH radical scavenging activity. At the concentration of 0.05 mg/ml, ascorbic acid (Vc), butylated hydroxytoluene (BHT) and rutin showed 92.8%, 58.8%, and 90.4% inhibition, respectively. In addition, rutin had effective inhibition of lipid peroxidation. Those various antioxidant activities were compared to standard antioxidants such as BHT and Vc.

In vitro antioxidant properties of rutin

Partial transmit sequence (PTS) technique is considered as one of the efficient methods to reduce the high peak-to-average power ratio (PAPR) problem in 4G waveform design such as the orthogonal frequency division multiplexing (OFDM) systems. Filtered-OFDM (F-OFDM) is a new candidate in the 5G waveform development with maintaining a high level of commonality with legacy OFDM systems, but the high PAPR value is still a considerable problem because F-OFDM supports the orthogonal transmission. Although the PTS technique improves the PAPR reduction performance significantly, the high computational complexity level for optimizing the phases of the transmitting signal restricts this technique in practical applications. Therefore, the low computational complexity level of the PTS technique leads to the adoption of this technique for PAPR reduction in the multicarrier systems such as OFDM and F-OFDM. In this paper, a new low complexity algorithm (Gray-PF-PTS) by combining the Gray code and the left feedback shift register operation based on a specific mapping rule has been proposed. The numerical results indicate that the Gray-PF-PTS algorithm extensively reduces the computational complexity level without degradation the PAPR reduction performance compared with the conventional PTS method. Furthermore, the OFDM and F-OFDM systems based on the Gray-PF-PTS algorithm have been compared regarding the PAPR, bit error rate (BER), and power spectrum density (PSD) performances.

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Reducing PAPR With Low Complexity for 4G and 5G Waveform Designs

Xanthine oxidase (XO) is a molybdoflavoprotein that catalyzes the oxidative hydroxylation of purines to produce uric acid and reactive oxygen species. These reaction products can cause severe disea...

Xanthine oxidase inhibitors: patent landscape and clinical development (2015-2020).

Design, synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives as novel xanthine oxidase inhibitors.

Peak to average power ratio reduction in OFDM system using hybrid technique

Two series of benzoflavone derivatives were rationally designed, synthesized and evaluated for their xanthine oxidase (XO) inhibitory potential. Among both series, eight compounds (NF-2, NF-4, NF-9, NF-12, NF-16, NF-25, NF-28, and NF-32) were found to exert significant XO inhibition with IC50 values lower than 10 μM. Enzyme kinetic studies revealed that the most potent benzoflavone derivatives (NF-4 and NF-28) are mixed type inhibitors of the XO enzyme. Molecular modeling studies were also performed to investigate the binding interactions of these molecules (NF-4 and NF-28) with the amino acid residues present in the active site of the enzyme. Docking results confirmed that their favorable binding conformations in the active site of XO can completely block the catalytic activity of the enzyme. Benzoflavone derivatives exhibiting potent XO enzyme inhibition also showed promising results in a hyperuricemic mice model when tested in vivo.

Benzoflavone derivatives as potent antihyperuricemic agents.

Roylea cinerea (D. Don) Baill. (Lamiaceae) is an indigenous plant of Western Himalayas, and has been used by the native population for the treatment of various diseases such as fever, malaria, diabetes, jaundice, and skin ailments. However, limited proportion of pharmacological and toxicological information is available on the bioactive properties of this plant. Therefore, the present study was designed to explore the anti-oxidant and anti-proliferative activities of Roylea cinerea. Methanolic extracts of leaves and stem of Roylea cinerea were prepared through maceration procedure and evaluated for the antioxidant activity using hydrogen/electron donating and hydroxyl radical scavenging assay. Significant antioxidant activity was observed for the methanolic extract of leaves in DPPH (EC50 239 µg/ml), molybdate ion reduction assay (29.73 µg ascorbic acid equivalent/mg dry weight of extract) as well as in plasmid nicking assay. Anti-proliferative and apoptotic activity in L6 rat skeletal muscle cell line was done using in vitro assays, i.e., MTT, Lactate dehydrogenase, mitochondrial membrane potential assay along with phase contrast, confocal, and scanning electron microscopy. The methanol extract of leaves and stem inhibited the growth of L6 cells with IC50 value of 69.41µg/ml and 124.93 µg/ml, respectively, and the lactate dehydrogenase activity was 20.29% and 0.3%, respectively. Cell cycle analysis by flow cytometry exhibited the arrest of cells in G1 and sub-G1 phase by methanolic leaves extract. Furthermore, the results of microscopic and docking analysis strengthened the observation made in the present study regarding the apoptotic mode of cell death in the L6 cell line. The in vitro findings of our studies revealed that the bioactive ingredients present in the methanolic extract of leaves and stem of Roylea cinerea have the anticancer potential. Further in vivo studies are needed to verify the in vitro results.

/pdf/antiproliferative-effects-of-roylea-cinerea-d-don-baillon-2vr7rwpi4d.pdf

Antiproliferative Effects of Roylea cinerea (D. Don) Baillon Leaves in Immortalized L6 Rat Skeletal Muscle Cell Line: Role of Reactive Oxygen Species Mediated Pathway.

An algorithm is a well-defined way that takes some input in the form of certain values, processes them and gives certain values as output. Although there is a large variety of sorting algorithms, sorting problem has appealed a great deal of research; because effective sorting is important to enhance the use of other algorithms.A novel sorting algorithm namely „V-Re-Fr (VRF) Sorting Algorithm‟ is proposed to address the limitations of the current popular sorting algorithms. The goal of this paper is to propose a new algorithm which will provide improved functionality and reduce algorithm complexities. The observations backed by literature survey indicates that proposed algorithm is much more efficient in terms of number of swaps or iterations than the other algorithms having O(n2) complexity, like insertion, selection and bubble sort algorithms.

VRF: A Novel Algorithm for optimized Sorting

Drug discovery process, Disease detection and Prediction of molecular class are the area of great significance for carrying out research. In past few decades some precise approaches were used to enhance the accuracy of Human protein Function (HPF) prediction. This research study is primarily concentrated on such approach of HPF prediction with sequence derived features (SDF) using decision trees and there variants implemented using C5 and C4.5 algorithms like See5 and SIPINA. More sequence derived features were identified and incorporated. The training data was improved with these incorporated features. The Sequence data was evolved from HPRD (Human protein reference database) in terms of number of sequences and the features used to extract the relation towards a specific class which enhancing power of training data. Multiple techniques were examined for accuracy in prediction and a widespread comparison was done amongst them incorporating with previous research results, and prescribed the overall accuracy of See5 with 64% and SIPINA with 88%. Keywords— HPF, C5, C4.5, See5, Decision Tree, SDF,

Amritpal Singh

Papers

Peak to average power ratio reduction in OFDM system using hybrid technique

Benzoflavone derivatives as potent antihyperuricemic agents.

Antiproliferative Effects of Roylea cinerea (D. Don) Baillon Leaves in Immortalized L6 Rat Skeletal Muscle Cell Line: Role of Reactive Oxygen Species Mediated Pathway.

VRF: A Novel Algorithm for optimized Sorting

Harnessing Power of Decision Tree Approach for HPF Prediction using SIPINA and See5