K
Kunal Nepali
Researcher at Taipei Medical University
Publications - 90
Citations - 2851
Kunal Nepali is an academic researcher from Taipei Medical University. The author has contributed to research in topics: Xanthine oxidase & Medicine. The author has an hindex of 27, co-authored 81 publications receiving 2024 citations. Previous affiliations of Kunal Nepali include Guru Nanak Dev University.
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Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids
TL;DR: A detailed account of the design strategies employed for the synthesis of anticancer agents via molecular hybridization techniques is offered and the structure activity relationship along with mechanistic insights revealed during the biological evaluation of the hybrids are highlighted.
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Nitro-Group-Containing Drugs
TL;DR: The current Perspective covers various aspects of agents that contain nitro groups, their bioreductive activation mechanisms, their toxicities, and approaches to combat their toxicity issues.
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The value of pyrans as anticancer scaffolds in medicinal chemistry
Dinesh Kumar,Pooja Sharma,Harmanpreet Singh,Kunal Nepali,Girish Kumar Gupta,Subheet Kumar Jain,Fidele Ntie-Kang,Fidele Ntie-Kang +7 more
TL;DR: The promising activities revealed by these pyran-based scaffolds undoubtedly place them at the forefront for the discovery of prospective drug candidates, and could therefore be of great interest to researchers working on the synthesis of antitumour drug candidates.
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Idiopathic pulmonary fibrosis: Current status, recent progress, and emerging targets
TL;DR: This review article presents the pathogenesis, therapeutic interventions, treatment approaches, and strategies employed for the design of antifibrotic agents for the treatment of IPF along with the patent literature from the past 10 years.
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A rational approach for the design and synthesis of 1-acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles as a new class of potential non-purine xanthine oxidase inhibitors.
Kunal Nepali,Gurinderdeep Singh,Anil Turan,Amit Agarwal,Sameer Sapra,Raj Kumar,Uttam Chand Banerjee,Prabhakar Kumar Verma,Naresh Kumar Satti,Manish K. Gupta,Om Parkash Suri,K. L. Dhar +11 more
TL;DR: The compound 59 emerged as the most potent XO inhibitor (IC(50)=5.3 μM), and some of the important interactions of 59 with the amino acid residues of active site of XO have been figured out by molecular modeling.