S
Sahil Sharma
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 73
Citations - 2228
Sahil Sharma is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Xanthine oxidase & Docking (molecular). The author has an hindex of 24, co-authored 65 publications receiving 1571 citations. Previous affiliations of Sahil Sharma include Guru Nanak Dev University & Kettering University.
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Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids
TL;DR: A detailed account of the design strategies employed for the synthesis of anticancer agents via molecular hybridization techniques is offered and the structure activity relationship along with mechanistic insights revealed during the biological evaluation of the hybrids are highlighted.
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Adapting to stress - chaperome networks in cancer.
TL;DR: It is argued that in cancer cells, a state of chaperomes hyperconnectivity is obtained by increasing the interaction strength among chaperome machinery members, and this concept will change how drugs targeting the chaperite to treat cancer are developed and implemented.
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Rational Approaches, Design Strategies, Structure Activity Relationship and Mechanistic Insights for Esterase Inhibitors
Harbinder Singh,Jatinder Vir Singh,Navdeep Kaur,Mohit Sanduja,Gurpreet Singh,Preet Mohinder Singh Bedi,Sahil Sharma +6 more
TL;DR: Rivastigmine derivatives, tacrine-piperazine hybrid, coumarin-benzofuran derivative, and phenylcinnamide derivative found to be exerting cholinesterase inhibition with IC50 below the range of 1 nM, place them in forefront as potential future drug candidates to further develop potent and specific esterase inhibitors.
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Anti-Cancer Pyrimidines in Diverse Scaffolds: A Review of Patent Literature
Ramandeep Kaur,Prabhkirat Kaur,Sahil Sharma,Gurpreet Singh,Samir Mehndiratta,Preet Mohinder Singh Bedi,Kunal Nepali +6 more
TL;DR: The structure of the potent compounds, their IC50 values, models/assays used for the anticancer evaluation and the enzymes/ receptors/ targets involved have been presented in this compilation.
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Xanthine oxidase inhibitors: a patent survey.
TL;DR: This review describes the patent literature covering both purine and non-purine analogs as xanthine oxidase inhibitors, up to December 2010, together with their recent highlights in pharmacology to gain an in-depth knowledge of patents covered and compounds discussed with their therapeutic use.