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Amy J. Sehnert
Researcher at University of California, San Francisco
Publications - 7
Citations - 697
Amy J. Sehnert is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Denaturing high performance liquid chromatography & Phospholipid transfer protein. The author has an hindex of 6, co-authored 7 publications receiving 646 citations. Previous affiliations of Amy J. Sehnert include Harvard University.
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Journal ArticleDOI
Cardiac troponin T is essential in sarcomere assembly and cardiac contractility.
Amy J. Sehnert,Anja Huq,Brant M. Weinstein,Charline Walker,Mark C. Fishman,Didier Y.R. Stainier +5 more
TL;DR: It is postulated that some mutations in tnnt2 may trigger misregulation of thin-filament protein expression, resulting in sarcomere loss and myocyte disarray, the life-threatening hallmarks of TNNT2 mutations in mice and humans.
Journal ArticleDOI
A window to the heart: can zebrafish mutants help us understand heart disease in humans?
TL;DR: Studies of zebrafish mutants with defective heart function are providing insight into the genes required to generate a normal heartbeat.
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Genetic variation of PLTP modulates lipoprotein profiles in hypoalphalipoproteinemia
Bradley E. Aouizerat,Mary B. Engler,Yanina Natanzon,Medha V. Kulkarni,James Song,Celeste Eng,Jarkko Huuskonen,Christopher R. Rivera,Annie Poon,Matt Bensley,Amy J. Sehnert,Christian Zellner,Mary J. Malloy,John P. Kane,Clive R. Pullinger +14 more
TL;DR: Findings indicate that PLTP gene variation is an important determinant of plasma lipoproteins and affects disorders of HDL metabolism.
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Genetic variation in phospholipid transfer protein modulates lipoprotein profiles in hyperalphalipoproteinemia
Mary B. Engler,Clive R. Pullinger,Mary J. Malloy,Yanina Natanzon,Medha V. Kulkarni,James Song,Celeste Eng,Jaarko Huuskonen,Christopher R. Rivera,Annie Poon,Matt Bensley,Amy J. Sehnert,Christian Zellner,John P. Kane,Bradley E. Aouizerat +14 more
TL;DR: The association of rs2294213 with HDL-C levels into the extremes of the HDL distribution is extended, and Linear regression models predict that possession of the rs2304213 minor allele increases LDL-C independent of triglycerides.
Journal ArticleDOI
In vivo regulation of the chicken cardiac troponin T gene promoter in zebrafish embryos.
William E. Tidyman,Amy J. Sehnert,Anja Huq,Jennifer Agard,Fiona M. Deegan,Didier Y.R. Stainier,Charles P. Ordahl +6 more
TL;DR: The PARP‐I transcriptional regulatory mechanism that governs muscle specificity of the chicken cTnT promoter is conserved across several chordate classes spanning at least 350 million years of evolution.