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Ana Agua-Doce
Researcher at Instituto de Medicina Molecular
Publications - 31
Citations - 1459
Ana Agua-Doce is an academic researcher from Instituto de Medicina Molecular. The author has contributed to research in topics: T cell & Immune tolerance. The author has an hindex of 15, co-authored 30 publications receiving 1225 citations. Previous affiliations of Ana Agua-Doce include Instituto Gulbenkian de Ciência & University of Lisbon.
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Journal ArticleDOI
Regulation of the Germinal Center Reaction by Foxp3+ Follicular Regulatory T Cells
Ivonne Wollenberg,Ana Agua-Doce,Ana Agua-Doce,Andrea Hernández,Catarina F. Almeida,Catarina F. Almeida,Vanessa G. Oliveira,Vanessa G. Oliveira,Jose Faro,Jose Faro,Luis Graca,Luis Graca +11 more
TL;DR: In vivo data show that Foxp3+ follicular T cells can limit the magnitude of the GC reaction and also the amount of secreted Ag-specific IgM, IgG1, Igg2b, and IgA, which appears to combine characteristics of TFH and regulatory T cells for the control of humoral immune responses.
Journal ArticleDOI
Identification of Regulatory Foxp3+ Invariant NKT Cells Induced by TGF-β
Marta Monteiro,Catarina F. Almeida,Marta Caridade,Julie C. Ribot,Joana Duarte,Ana Agua-Doce,Ivonne Wollenberg,Bruno Silva-Santos,Luis Graca +8 more
TL;DR: An unexpected capacity of iNKT cells to acquire regulatory functions that may contribute to the establishment of immunological tolerance is unveiled.
Journal ArticleDOI
Human blood Tfr cells are indicators of ongoing humoral activity not fully licensed with suppressive function
Válter R. Fonseca,Ana Agua-Doce,Ana Agua-Doce,Ana Raquel Maceiras,Ana Raquel Maceiras,Wim Pierson,F. N. Ribeiro,F. N. Ribeiro,Vasco C. Romão,Ana R. Pires,Susana L. Silva,João Eurico Fonseca,Ana E. Sousa,Michelle A. Linterman,Luis Graca,Luis Graca +15 more
TL;DR: It is found that blood Tfr cells are increased in Sjögren syndrome, an autoimmune disease with ongoing GC reactions, especially in patients with high autoantibody titers, as well as in healthy individuals upon influenza vaccination, and they lack full B cell–suppressive capacity, despite being able to suppress T cell proliferation.
Journal ArticleDOI
The Ratio of Blood T Follicular Regulatory Cells to T Follicular Helper Cells Marks Ectopic Lymphoid Structure Formation While Activated Follicular Helper T Cells Indicate Disease Activity in Primary Sjögren's Syndrome
Válter R. Fonseca,Vasco C. Romão,Ana Agua-Doce,Mara Santos,Dolores López-Presa,Ana Cristina Ferreira,João Eurico Fonseca,Luis Graca +7 more
TL;DR: To investigate whether the balance of blood follicular helper T (Tfh) cells and T follicular regulatory (Tfr) cells can provide information about ectopic lymphoid neogenesis and disease activity in primary Sjögren's syndrome (SS).
Journal ArticleDOI
What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?
Rita N. Bárcia,Jorge M. Santos,Mariana Filipe,Mariana Teixeira,José Paulo Martins,Joana Almeida,Ana Agua-Doce,S. Almeida,A. Varela,S. Pohl,Kurt E.J. Dittmar,Susana Calado,Sandra Simões,Maria Manuela Gaspar,M.E.M. Cruz,Werner Lindenmaier,Luis Graca,Helder Cruz,Pedro Estilita Monteiro Da Cruz +18 more
TL;DR: UCX seem to be naturally more potent immunosuppressors and less immunogenic than BM-MSCs, and it is proposed that these differences may be due to increased levels of immunomodulatory surface proteins such as CD200, CD273, CD274 and cytokines such as IL1β, IL-8, LIF and TGFβ2.