Ana Maria Raymundi

TL;DR: The present results suggest the CBD disrupts the consolidation of different fear memories via anandamide-mediated activation of DH CB1 and CB2 receptors.

TL;DR: Cannabidiol mitigates fear memories by facilitating their extinction or interfering with their generalization and reconsolidation in the dorsal hippocampus during contextual fear consolidation.

TL;DR: Current evidence from healthy humans and PTSD patients supports the THC value to suppress anxiety and aversive memory expression without producing significant adverse effects if used in low doses or when associated with CBD.

TL;DR: It is shown that prelimbic cortex PKC and PKMζ are involved in memory reconsolidation and persistence and that omitting memory reactivation prevented the chelerythrine- and ZIP-induced effects.

TL;DR: The present study evaluated the effect of the selective PDE4 inhibitor roflumilast on acquisition and consolidation of the extinction of fear memory in male Wistar rats in a contextual fear conditioning paradigm and suggested that cAMP-PKA activity in the IL during the late consolidation phase after extinction learning underlies the persistence of extinction.