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Ana Pastora Otero-Motta
Researcher at Spanish National Research Council
Publications - 4
Citations - 184
Ana Pastora Otero-Motta is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Gene expression & RNA interference. The author has an hindex of 4, co-authored 4 publications receiving 176 citations.
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Journal ArticleDOI
Stable interference of EWS–FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target
D. Herrero-Martin,D. Osuna,José Luis Ordóñez,V. Sevillano,A. S. Martins,Carlos Mackintosh,M J Campos,J. Madoz-Gurpide,Ana Pastora Otero-Motta,G. Caballero,Ana Teresa Amaral,Daniel H. Wai,Yvonne Braun,Martin Eisenacher,Martin Eisenacher,Karl-Ludwig Schaefer,Christopher Poremba,E. de Álava +17 more
TL;DR: This is the first report of TOPK activity in Ewing Sarcoma and suggests a significant role of this MAPKK-like protein kinase in the Ewing sarcoma biology.
Journal ArticleDOI
The Clinical Relevance of Molecular Genetics in Soft Tissue Sarcomas
José Luis Ordóñez,Daniel Osuna,Daniel J. García-Domínguez,Ana Teresa Amaral,Ana Pastora Otero-Motta,Carlos Mackintosh,María Victoria Sevillano,María Victoria Barbado,Teresa Hernández,Enrique de Alava +9 more
TL;DR: The discovery of the early mechanisms involved in the genesis of sarcomas, the more relevant signaling pathways, and the development of genetically engineered mouse models could also provide a new individualized therapeutic strategy against these tumors.
Journal ArticleDOI
Prevalence of human papillomavirus genotypes in cytologic abnormalities from unvaccinated women living in north-western Spain
Ana Pastora Otero-Motta,José Luis Ordóñez,Rafael González-Celador,Belen Rivas,María Del Carmen García Macías,Agustín Bullón,María Del Mar Abad +6 more
TL;DR: The prevalence of human papillomavirus genotypes in cytologic abnormalities from unvaccinated women living in north‐western Spain is low, but the number of cases is high and the risks of adverse events are high.
Journal ArticleDOI
Innovative therapies in Ewing Sarcoma.
Ana Teresa Amaral,José Luis Ordóñez,Ana Pastora Otero-Motta,Daniel J. García-Domínguez,María Victoria Sevillano,Enrique de Alava +5 more
TL;DR: This review focuses on the research on targeted therapies in Ewing Sarcoma, and discussed some bottlenecks related to this such as the possible role of pathologists, the availability of samples, the lack of appropriate animal models, and the resources needed to carry out preclinical and clinical research.