Anastasia Efimenko

TL;DR: It is shown that in co-culture ASCs enhance blood vessel growth not only by production of paracrine-acting factors but also by promoting the endothelial differentiation of cardiac progenitor cells, which could be beneficial for the stimulation of angiogenesis in ischemic tissues by ASCs administration.

TL;DR: The hypothesis that autologous ADSC from aged subjects might have an impaired therapeutic potential is supported, including impaired proliferation and angiogenic stimulation.

TL;DR: ADSCs from aged patients both with and without CAD acquire aging characteristics, and their angiogenic potential declines because of decreasing proangiogenic factor secretion, which could restrict the effectiveness of autologous cell therapy with ADSCs in aged patients.

TL;DR: Variability in the secretion of several proteins from cultured ADSCs of individual subjects suggests that these cells exist as a heterogeneous population containing functionally distinct subtypes, which differ in numbers between donors.

TL;DR: In this paper, the authors used regression analysis to predict associations between concentrations of several components of MSC-CM and its biological activity to stimulate human dermal fibroblast and endothelial cell migration in vitro.