André Bélanger

TL;DR: Pyrrolecarboxylate ester the active insecticidal component in the roots and stems of Ryana speciosa binds nearly irreversibly to sarcoplasmic reticulum vesicles; binding studies intentified calcium release channels now known as Ryanodine receptors.

TL;DR: In this paper, the authors report several model studies that were necessary for the rational conception of a simple four-step synthesis (6 + S + (S)-74, S + S (S) 74, S+S (S), S −74, E −81a −b, B −b) of the carbonate derivative 8.

TL;DR: In this paper, a retrosynthetic analysis that led to the conception of a synthetic strategy for the construction of ryanodol was presented, leading to the preparation of a key diene, i.e., spirolactone dienone 47.

TL;DR: The authors reported the transformation of (+)-anhydroryanodol to (+)-ryanodol by reductive cyclization of lactone epoxide derivatives 9 and 20 (Scheme 4).

TL;DR: This paper reported several studies that were carried out to learn how to transform the dextrorotatory pentacyclic key intermediate 5 into (+)-anhydroryanodol (6).