F
Fabrizio Marazza
Publications - 5
Citations - 198
Fabrizio Marazza is an academic researcher. The author has contributed to research in topics: Total synthesis & Retrosynthetic analysis. The author has an hindex of 5, co-authored 5 publications receiving 195 citations.
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Journal ArticleDOI
Total synthesis of ryanodol
André Bélanger,Daniel J. F. Berney,H.-Jürg Borschberg,Robert Brousseau,Alain Doutheau,Robert Durand,Hajime Katayama,Richard Lapalme,Dominique M. Leturc,Chun-Chen Liao,Fred N. MacLachlan,Jean-Pierre Maffrand,Fabrizio Marazza,Robert Martino,Claude Moreau,Louiselle Saint-Laurent,Roger Saintonge,Pierre Soucy,Luc Ruest,Pierre Deslongchamps +19 more
TL;DR: Pyrrolecarboxylate ester the active insecticidal component in the roots and stems of Ryana speciosa binds nearly irreversibly to sarcoplasmic reticulum vesicles; binding studies intentified calcium release channels now known as Ryanodine receptors.
Journal ArticleDOI
The total synthesis of (+)-ryanodol. Part II. Model studies for rings B and C of (+)-anhydroryanodol. Preparation of a key pentacyclic intermediate
Pierre Deslongchamps,André Bélanger,Daniel J. F. Berney,Hans-Juerg Borschberg,Robert Brousseau,Alain Doutheau,Robert Durand,Hajime Katayama,Richard Lapalme,Dominique M. Leturc,Chun-Chen Liao,Frederick N. MacLachlan,Jean-Pierre Maffrand,Fabrizio Marazza,Robert Martino,Claude Moreau,Luc Ruest,Louiselle Saint-Laurent,Roger Saintonge,Pierre Soucy +19 more
TL;DR: In this paper, the authors report several model studies that were necessary for the rational conception of a simple four-step synthesis (6 + S + (S)-74, S + S (S) 74, S+S (S), S −74, E −81a −b, B −b) of the carbonate derivative 8.
Journal ArticleDOI
The total synthesis of (+)-ryanodol. Part I. General strategy and search for a convenient diene for the construction of a key tricyclic intermediate
Pierre Deslongchamps,André Bélanger,Daniel J. F. Berney,Hans-Juerg Borschberg,Robert Brousseau,Alain Doutheau,Robert Durand,Hajime Katayama,Richard Lapalme,Dominique M. Leturc,Chun-Chen Liao,Frederick N. MacLachlan,Jean-Pierre Maffrand,Fabrizio Marazza,Robert Martino,Claude Moreau,Luc Ruest,Louiselle Saint-Laurent,Roger Saintonge,Pierre Soucy +19 more
TL;DR: In this paper, a retrosynthetic analysis that led to the conception of a synthetic strategy for the construction of ryanodol was presented, leading to the preparation of a key diene, i.e., spirolactone dienone 47.
Journal ArticleDOI
The total synthesis of (+)-ryanodol. Part IV. Preparation of (+)-ryanodol from (+)-anhydroryanodol
Pierre Deslongchamps,André Bélanger,Daniel J. F. Berney,Hans-Jürg Borschberg,Robert Brousseau,Alain Doutheau,Robert Durand,Hajime Katayama,Richard Lapalme,Dominique M. Leturc,Chun-Chen Liao,Frederick N. MacLachlan,Jean-Pierre Maffrand,Fabrizio Marazza,Robert Martino,Claude Moreau,Luc Ruest,Louiselle Saint-Laurent,Roger Saintonge,Pierre Soucy +19 more
TL;DR: The authors reported the transformation of (+)-anhydroryanodol to (+)-ryanodol by reductive cyclization of lactone epoxide derivatives 9 and 20 (Scheme 4).
Journal ArticleDOI
The total synthesis of (+)-ryanodol. Part III. Preparation of (+)-anhydroryanodol from a key pentacyclic intermediate
Pierre Deslongchamps,André Bélanger,Daniel J. F. Berney,Hans-Juerg Borschberg,Robert Brousseau,Alain Doutheau,Robert Durand,Hajime Katayama,Richard Lapalme,Dominique M. Leturc,Chun-Chen Liao,Frederick N. MacLachlan,Jean-Pierre Maffrand,Fabrizio Marazza,Robert Martino,Claude Moreau,Luc Ruest,Louiselle Saint-Laurent,Roger Saintonge,Pierre Soucy +19 more
TL;DR: This paper reported several studies that were carried out to learn how to transform the dextrorotatory pentacyclic key intermediate 5 into (+)-anhydroryanodol (6).