Andre Stander

TL;DR: Cell cycle analysis showed an increase in the number of cells in the G2/M fraction after 24 h and an increase of cell in the sub‐G1 fraction after 48’h, indicating that the compounds are antimitotic and able to induce apoptosis.

TL;DR: The preliminary study demonstrates that S. frutescens water extracts exert a differential action mechanism in non-tumorigenic MCF-12A cells when compared to tumorigenicMCF-7 cells, warranting future studies on this multi-purpose medicinal plant in southern Africa.

TL;DR: It was demonstrated that ESE-16 induces cell death via both autophagy and apoptosis in esophageal carcinoma cells, paving the way for future investigation into the role of ESE -16 in ex vivo and in vivo studies as a possible anticancer agent.

TL;DR: The carcinogenicMCF-7 cell line is revealed to be more susceptible to the cytostatic and cytotoxic effects of aqueous extracts of Sutherlandia frutescens when compared to the non-tumorigenic MCF-12A cell line, thus warranting further research into the exact cellular mechanisms involved and the possible synergistic activities of Sutherlandian shrub ingredients.

TL;DR: Electrophoresis, viscometry, UV‐vis, CD and LD spectroscopy suggest the cytotoxic [AuIII(CNC)Cl]+ complex behaves as a partial DNA intercalator, and both the redox stability and DNA affinity of the hit compound might be key factors underpinning its cytotoxicity in vitro.