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Andrea Castro
Researcher at University of Chile
Publications - 39
Citations - 1087
Andrea Castro is an academic researcher from University of Chile. The author has contributed to research in topics: Azoospermia & Y chromosome microdeletion. The author has an hindex of 16, co-authored 37 publications receiving 977 citations.
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Journal ArticleDOI
Increased sperm DNA damage in patients with varicocele: relationship with seminal oxidative stress
Rosita Smith,Heidy Kaune,Daniela Parodi,Marcia Madariaga,Rafael Ríos,Ignacio Morales,Andrea Castro +6 more
TL;DR: The results indicate that oxidative damage is associated with sperm DNA damage in patients with varicocele and that high levels of DNA-damage spermatozoa even in the presence of normal semen profile are found.
Journal ArticleDOI
Effect of an intrauterine device on the gene expression profile of the endometrium.
José A. Horcajadas,Andrew M. Sharkey,R. D. Catalano,J. R. A. Sherwin,Francisco Domínguez,L. A. Burgos,Andrea Castro,M. R. Peraza,Antonio Pellicer,Carlos Simón +9 more
TL;DR: The results reveal that a refractory endometrium in a fertile woman produced by an IUD is induced by preventing the normal transition to a receptive gene expression profile through effects on a specific subset or cluster of genes that impact on endometrial receptivity.
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Testis development in the absence of SRY: Chromosomal rearrangements at SOX9 and SOX3
Annalisa Vetro,Mohammadreza Dehghani,Lilia Kraoua,Roberto Giorda,Silvana Beri,Laura Cardarelli,Maurizio Merico,Emmanouil Manolakos,Alexis Parada-Bustamante,Andrea Castro,Orietta Radi,Giovanna Camerino,Alfredo Brusco,Marjan Sabaghian,Crystalena Sofocleous,Francesca Forzano,Pietro Palumbo,Orazio Palumbo,Savino Calvano,Leopoldo Zelante,Paola Grammatico,Sabrina Giglio,Mohamed Basly,M. Chaabouni,Massimo Carella,Gianni Russo,Maria Clara Bonaglia,Orsetta Zuffardi +27 more
TL;DR: Collectively in this cohort of 19 novel cases of SRY-negative 46,XX DSD, the duplications upstream of SOX9 account for ~10.5% of the cases, and are responsible for the disease phenotype, even when inherited from a normal father.
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Quantification of DDX3Y, RBMY1, DAZ and TSPY mRNAs in testes of patients with severe impairment of spermatogenesis
María Cecilia Lardone,Daniela Parodi,Raúl Valdevenito,Mauricio Ebensperger,A. Piottante,Marcia Madariaga,Rosita Smith,Ricardo Pommer,N. Zambrano,Andrea Castro +9 more
TL;DR: The finding that the testicular transcript of DDX3Y is significantly decreased in patients with severe spermatogenenic failure, especially in those presenting maturation arrest, suggests an important role of DDx3Y during sperMatogenesis.
Journal ArticleDOI
Aumento del daño en el ADN y estrés oxidativo en espermatozoides de pacientes con oligozoospermia idiopática y antecedentes de criptorquidismo
Rosita Smith,Heidy Kaune,Daniela Parodi,Marcia Madariaga,Ignacio Morales,Rafael Ríos,Andrea Castro +6 more
TL;DR: Sperm DNAdamage was evaluated by the sperm chromatin structure assay/flow cytometry and by thedUTP-biotin nick end labeling (TUNEL) assay and levels of reactive oxygen species (ROS) and totalantioxidant capacity (TAC) were assessed by a chemiluminescence assay.