A
Andrea Li Ann Wong
Researcher at National University of Singapore
Publications - 78
Citations - 1835
Andrea Li Ann Wong is an academic researcher from National University of Singapore. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 19, co-authored 67 publications receiving 1212 citations. Previous affiliations of Andrea Li Ann Wong include National University of Health Sciences & University Health System.
Papers
More filters
Journal ArticleDOI
Do STAT3 inhibitors have potential in the future for cancer therapy
Andrea Li Ann Wong,Jayshree L. Hirpara,Shazib Pervaiz,Jie-Qing Eu,Gautam Sethi,Boon Cher Goh +5 more
TL;DR: Signal transduction activator of transcription (STAT) 3 is a member of the STAT protein family which transduces intracellular and extracellular signals to the nucleus, controlling the expression of transcription factors in the nucleus.
Journal ArticleDOI
Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies
Andrea Li Ann Wong,Andrea Li Ann Wong,Ross A. Soo,Ross A. Soo,David S.P. Tan,Soo-Chin Lee,Soo-Chin Lee,Joline Si Jing Lim,Joline Si Jing Lim,Patrick Marban,Li Ren Kong,Y.J. Lee,Lingzhi Wang,Win Lwin Thuya,Richie Soong,M.Q. Yee,T.M. Chin,T.M. Chin,M.T. Cordero,B.R. Asuncion,Brendan Pang,Shazib Pervaiz,Jayshree L. Hirpara,Arvind Kumar Sinha,W.W. Xu,Miyuki Yuasa,Takeshi Tsunoda,Masaaki Motoyama,Toshimasa Yamauchi,Boon Cher Goh +29 more
TL;DR: OPB-51602 demonstrates promising antitumor activity, particularly in NSCLC, and its long half-life and poorer tolerability of continuous dosing, compared with intermittent dosing suggest that less frequent dosing should be explored.
Journal ArticleDOI
Targeting STAT3 and oxidative phosphorylation in oncogene-addicted tumors.
Matilda Lee,Jayshree L. Hirpara,Jie-Qing Eu,Gautam Sethi,Lingzhi Wang,Boon Cher Goh,Andrea Li Ann Wong,Andrea Li Ann Wong +7 more
TL;DR: The role of STAT3 and OXPHOS are reviewed as targets of novel therapeutic strategies aimed at restoring drug sensitivity in treatment-resistant oncogene-addicted tumor types.
Journal ArticleDOI
Mechanisms of Resistance to Trastuzumab and Novel Therapeutic Strategies in HER2-Positive Breast Cancer
Andrea Li Ann Wong,Soo-Chin Lee +1 more
TL;DR: This paper summarizes existing preclinical and clinical evidence on the mechanisms of trastuzumab action and resistance and provides an up-to-date overview of novel HER2-directed therapies in clinical development.
Journal ArticleDOI
Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistance.
Jayshree L. Hirpara,Jie Qing Eu,Joanna Kia Min Tan,Andrea Li Ann Wong,Marie-Veronique Clement,Li Ren Kong,Naoto Ohi,Takeshi Tsunoda,Jianhua Qu,Boon Cher Goh,Shazib Pervaiz +10 more
TL;DR: Evidence is reported of enhanced reliance on mitochondrial oxidative phosphorylation (OXPHOS) in oncogene-addicted cancers manifesting acquired resistance to targeted therapies, and a novel OXPHOS targeting activity of the small molecule compound, OPB-51602 (OPB).