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Andreas Emmendoerffer
Researcher at Fraunhofer Society
Publications - 6
Citations - 278
Andreas Emmendoerffer is an academic researcher from Fraunhofer Society. The author has contributed to research in topics: Congenital Neutropenia & Binding site. The author has an hindex of 6, co-authored 6 publications receiving 264 citations.
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Journal ArticleDOI
Functional features of neutrophils induced by G-CSF and GM-CSF treatment: differential effects and clinical implications
TL;DR: This review summarizes major functional and phenotypical features of neutrophils induced by G-CSF treatment in patients with acquired and congenital neutropenias and focuses on the differential effect of G- CSF and GM-SF on neutrophil function in vitro and in vivo.
Journal ArticleDOI
Role of inflammation in chemical-induced lung cancer
TL;DR: The extent of inflammatory response, type of genotoxic event, antagonizing principles and genetic background are discussed, and methods to assess the inflammatory potential of chemicals are referred to.
Journal ArticleDOI
Altered surface marker expression and function of G-CSF-induced neutrophils from test subjects and patients under chemotherapy.
Karsten Spiekermann,Andreas Emmendoerffer,Joern Elsner,Evelin Raeder,Evelin Raeder,M L Lohmann-Matthes,Arndt Prahst,Hartmut Link,Mathias Freund,Karl Welte,Joachim Roesler,Joachim Roesler +11 more
TL;DR: G‐CSF has profound effects on neutrophil phenotype and function in vivo which might have clinical implications in patients under cytotoxic chemotherapy and in healthy test subjects.
Journal ArticleDOI
Effects of glucocorticoids on the TPA-induced monocytic differentiation
TL;DR: Glucocorticoids interfere with TPA‐induced functions, which are typical for activated macrophages; however, they do not impair the differentiation process and concomitant growth inhibition.
Journal ArticleDOI
Changes in light‐scatter profile, membrane depolarization and calcium mobilization of neutrophils induced by G‐CSF in vivo
Karsten Spiekermann,Andreas Emmendoerffer,Elsner J,Evelin Raeder,Evelin Raeder,M L Lohmann-Matthes,Karl Welte,Joachim Roesler,Joachim Roesler +8 more
TL;DR: All the alterations found here are suggested to be caused by a partial immaturity of the neutrophils, although in vivo activation and a direct effect of G‐CSF on myeloid precursors might be involved.