Showing papers by "Andreas G. Ladurner published in 2005"
TL;DR: It is shown that human macroH2A1.1 binds the SirT1-metabolite O-acetyl-ADP-ribose (OAADPR) through its macro domain, and alternative splicing may regulate the binding of nicotinamide adenine dinucleotide (NAD) metabolites to chromatin.
Abstract: Histone macroH2A is a hallmark of mammalian heterochromatin. Here we show that human macroH2A1.1 binds the SirT1-metabolite O-acetyl-ADP-ribose (OAADPR) through its macro domain. The 1.6-A crystal structure and mutants reveal how the metabolite is recognized. Mutually exclusive exon use in the gene H2AFY produces macroH2A1.2, whose tissue distribution differs. MacroH2A1.2 shows only subtle structural changes but cannot bind nucleotides. Alternative splicing may thus regulate the binding of nicotinamide adenine dinucleotide (NAD) metabolites to chromatin.
300 citations
TL;DR: A new study shows that CtBP, a transcription corepressor, may mediate its effect by blocking histone acetylation, a mark of active transcription, thereby supporting a link between cellular metabolism and gene expression.
Abstract: A new study shows that CtBP, a transcription corepressor, may mediate its effect by blocking histone acetylation, a mark of active transcription. This activity is modulated by NADH binding, thereby supporting a link between cellular metabolism and gene expression.
4 citations