G
Georg Kustatscher
Researcher at University of Edinburgh
Publications - 25
Citations - 2179
Georg Kustatscher is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Proteomics & Chromatin. The author has an hindex of 11, co-authored 20 publications receiving 1831 citations. Previous affiliations of Georg Kustatscher include Salk Institute for Biological Studies & European Bioinformatics Institute.
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Journal ArticleDOI
The macro domain is an ADP-ribose binding module
Georgios I. Karras,Georg Kustatscher,Heeran R Buhecha,Mark D. Allen,Céline Pugieux,Fiona Sait,Mark Bycroft,Andreas G. Ladurner +7 more
TL;DR: In this article, the authors provide biochemical and structural evidence that macro domains are high affinity binding modules for ADP-ribose nucleotide nucleotides and reveal a conserved ligand binding pocket among the macro domain fold.
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A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation.
Gyula Timinszky,Susanne Till,Paul O. Hassa,Michael Hothorn,Georg Kustatscher,Bianca Nijmeijer,Julien Colombelli,Matthias Altmeyer,Ernst H. K. Stelzer,Klaus Scheffzek,Michael O. Hottiger,Andreas G. Ladurner +11 more
TL;DR: Macrodomains are identified as modules that directly sense PARP activation in vivo and establish macroH2A histones as dynamic regulators of chromatin plasticity.
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Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components
Constance Alabert,Jimi-Carlo Bukowski-Wills,Sung Bau Lee,Georg Kustatscher,Kyosuke Nakamura,Flavia de Lima Alves,Patrice Menard,Jakob Mejlvang,Juri Rappsilber,Juri Rappsilber,Anja Groth +10 more
TL;DR: This work uses nascent chromatin capture (NCC) to profile chromatin proteome dynamics during replication in human cells, and identifies FAM111A as a replication factor required for PCNA loading, providing an extensive resource to understand genome and epigenome maintenance.
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Splicing regulates NAD metabolite binding to histone macroH2A.
TL;DR: It is shown that human macroH2A1.1 binds the SirT1-metabolite O-acetyl-ADP-ribose (OAADPR) through its macro domain, and alternative splicing may regulate the binding of nicotinamide adenine dinucleotide (NAD) metabolites to chromatin.
Journal ArticleDOI
Histone macroH2A isoforms predict the risk of lung cancer recurrence
Judith C. Sporn,Georg Kustatscher,Torsten Hothorn,Manuel Collado,Manuel Serrano,Thomas Muley,Philipp A. Schnabel,Andreas G. Ladurner +7 more
TL;DR: It is shown that expression of histone macroH2A1.1 and macroH1A2 predicts lung cancer recurrence, identifying these histone variants as a novel tool for an improved risk stratification of cancer patients.