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Andreas Mades
Publications - 4
Citations - 389
Andreas Mades is an academic researcher. The author has contributed to research in topics: Immunotherapy & Chimeric antigen receptor. The author has an hindex of 3, co-authored 4 publications receiving 205 citations.
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Journal ArticleDOI
The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells
Katrin Mestermann,Theodoros Giavridis,Justus Weber,Julian Rydzek,Silke Frenz,Thomas Nerreter,Andreas Mades,Michel Sadelain,Hermann Einsele,Michael Hudecek +9 more
TL;DR: It is shown that treatment with dasatinib halts cytolytic activity, cytokine production, and proliferation of CAR T cells in vitro and in vivo, and in a mouse model of cytokine release syndrome, it is demonstrated that a short treatment course of dAsatinib, administered early after CAR T cell infusion, protects a proportion of mice from otherwise fatal CRS.
Journal ArticleDOI
A highly soluble Sleeping Beauty transposase improves control of gene insertion
Irma Querques,Andreas Mades,Cecilia Zuliani,Csaba Miskey,Miriam Alb,Esther Grueso,Markus Machwirth,Tobias Rausch,Hermann Einsele,Zoltán Ivics,Michael Hudecek,Orsolya Barabas +11 more
TL;DR: It is demonstrated that hsSB can be delivered with transposon DNA to genetically modify cell lines and embryonic, hematopoietic and induced pluripotent stem cells (iPSCs), overcoming uncontrolled transposase activity.
Journal ArticleDOI
CAR T cells targeting αvβ3 integrin are effective against advanced cancer in preclinical models.
TL;DR: Data establish αvβ3 integrin as a novel target for CAR T‐cell immunotherapy and affirm the previous notion that binding domain affinity and spacer length can be calibrated to augment CAR reactivity.
Patent
Ror1-specific chimeric antigen receptors (car) with humanized targeting domains
Michael Hudecek,Andreas Mades +1 more
TL;DR: In this paper, a humanized targeting domain specific to the antigen ROR1 was proposed for chimeric antigen receptors (CARs) with polynucleotides, vectors encoding CARs and isolated cells expressing them at their surface.