K
Katrin Mestermann
Publications - 8
Citations - 328
Katrin Mestermann is an academic researcher. The author has contributed to research in topics: Chimeric antigen receptor & Biology. The author has an hindex of 2, co-authored 5 publications receiving 160 citations.
Papers
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Journal ArticleDOI
The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells
Katrin Mestermann,Theodoros Giavridis,Justus Weber,Julian Rydzek,Silke Frenz,Thomas Nerreter,Andreas Mades,Michel Sadelain,Hermann Einsele,Michael Hudecek +9 more
TL;DR: It is shown that treatment with dasatinib halts cytolytic activity, cytokine production, and proliferation of CAR T cells in vitro and in vivo, and in a mouse model of cytokine release syndrome, it is demonstrated that a short treatment course of dAsatinib, administered early after CAR T cell infusion, protects a proportion of mice from otherwise fatal CRS.
Journal ArticleDOI
Siglec-6 is a novel target for CAR T-cell therapy in acute myeloid leukemia
Hardikkumar Jetani,Almudena Navarro-Bailón,Marius Maucher,Silke Frenz,Christina Verbruggen,Ana Yeguas,María Belén Vidriales,Marcos González,Judit Rial Saborido,Sabrina Kraus,Katrin Mestermann,Simone Thomas,Halvard Bonig,Maik Luu,Razieh Monjezi,Dimitrios Mougiakakos,Markus Sauer,Hermann Einsele,Michael Hudecek +18 more
TL;DR: Siglec-6 is commonly expressed on AML cell lines and primary AML blasts, including the subpopulation of AML stem cells and normal hematopoietic stem and progenitor cells (HSPCs) as discussed by the authors.
Journal ArticleDOI
Overcoming key challenges in cancer immunotherapy with engineered T cells.
Silvia Arcangeli,Katrin Mestermann,Justus Weber,Chiara Bonini,Monica Casucci,Michael Hudecek +5 more
TL;DR: This review focuses on the innovative approaches designed and tested to overcome the hurdles encountered so far in the clinical practice, with new excitement on novel laboratory insights and ongoing clinical investigations.
Journal ArticleDOI
ROR1-targeting switchable CAR-T cells for cancer therapy
Haiyong Peng,Thomas Nerreter,Katrin Mestermann,Jakob Wachter,Jing Chang,Michael Hudecek,Christoph Rader +6 more
TL;DR: In this paper , a panel of switches based on ROR1-targeting Fabs with different epitopes and affinities was compared in in in vitro and in vivo models of ROR-1-expressing cancers.
Book ChapterDOI
Generation of CAR-T Cells with Sleeping Beauty Transposon Gene Transfer.
Sabrina Prommersberger,R Monjezi,Lacramioara Botezatu,Csaba Miskey,Maximilian Amberger,Katrin Mestermann,Michael Hudecek,Zoltán Ivics +7 more
TL;DR: In this paper , the basic Sleeping Beauty transposon vector components required for stable gene integration in human cells, with special emphasis on minicircle DNA vectors and the use of synthetic mRNA, are described.