Andreas N. Kavazis

TL;DR: An overview of muscle proteases, outline intracellular sources of reactive oxygen species, and summarize the evidence that connects oxidative stress to signaling pathways contributing to disuse muscle atrophy are provided.

TL;DR: This review discusses the redox‐sensitive signalling pathways that are responsible for ROS‐induced skeletal muscle adaptation and discusses the evidence that connects redox signalling to skeletal muscle adaptations in response to increased muscular activity and during prolonged periods of muscular inactivity.

TL;DR: Ongoing research continues to explore the redox-sensitive targets in muscle that are responsible for both redox regulation of muscle adaptation and oxidant-mediated muscle fatigue.

TL;DR: This review will address the role of reactive oxygen species and oxidative stress as potential contributors to the process of disuse-mediated muscle atrophy, and highlight gaps in knowledge relative to the specific role of oxidative stress in the regulation of disuses.

TL;DR: Results reveal that prevention of mechanical ventilation-induced increases in diaphragmatic mitochondrial reactive oxygen species emission protects the diphragm from mechanical ventilation -induced diaphagmatic weakness, and indicates that mitochondria are a primary source of reactive oxygen Species production in the diaphragem during prolonged mechanical ventilation.