Upconversion photoluminescent Yb(Ⅲ)/Er(Ⅲ) doped nanoparticles interact with AuNPs for detection of Cr (Ⅲ) and sodium tripolyphosphate based on FRET

Determination of chromium(III) picolinate in dietary supplements by flow injection - electrospray ionization - tandem mass spectrometry, using cobalt(II) picolinate as internal standard

Maternal micronutrient disturbance as risks of offspring metabolic syndrome.

Effects of Chromium Supplementation on Lipid Profile: an Umbrella of Systematic Review and Meta-analysis

Abstract Hexavalent chromium (Cr (VI)) from environmental pollution shows severe toxicity towards human organs by causing oxidative damage. Apelin-13 may inhibit oxidative damage by blocking ROS accumulation and regulating multiple signals. However, whether apelin-13 can attenuate Cr (VI)-induced toxicity has not been explored. Herein, the protective effect and molecular mechanism of apelin-13 against K 2 Cr 2 O 7 -induced cardiotoxicity in vitro and in vivo were evaluated. Results show that apelin-13 significantly inhibited K 2 Cr 2 O 7 -induced H9c2 cytotoxicity and apoptosis, followed by the attenuated PARP cleavage and caspase activation. Further investigation revealed that apelin-13 co-treatment effectively suppressed K 2 Cr 2 O 7 -induced oxidative damage by inhibiting ROS accumulation. Moreover, apelin-13 co-treatment dramatically normalized MAPKs and PI3K/AKT pathways in K 2 Cr 2 O 7 -treated H9c2 cells. Importantly, apelin-13 administration in vivo effectively attenuated myocardial fibrosis, improved angiogenesis, and inhibited myocardial abnormal proliferation and apoptosis. Ultimately, it alleviated K 2 Cr 2 O 7 -induced myocardial injury in rats. Taken together, our findings validated the strategy of the use of apelin-13 to effectively combat Cr (VI)-induced myocardial injury. 

Andrej Belančić

Papers

The effect of chromium intake on oxidative stress parameters: A systematic review and meta-analysis.