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Andrew A. Somogyi
Researcher at University of Adelaide
Publications - 336
Citations - 13816
Andrew A. Somogyi is an academic researcher from University of Adelaide. The author has contributed to research in topics: Opioid & Methadone. The author has an hindex of 62, co-authored 323 publications receiving 12635 citations. Previous affiliations of Andrew A. Somogyi include Sir Charles Gairdner Hospital & Alfred Hospital.
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Journal ArticleDOI
Morphine activates neuroinflammation in a manner parallel to endotoxin
Xiaohui Wang,Lisa C. Loram,Khara M. Ramos,Armando J. de Jesus,Jacob Thomas,Kui Cheng,Anireddy S. N. Reddy,Andrew A. Somogyi,Mark R. Hutchinson,Linda R. Watkins,Hang Yin +10 more
TL;DR: It is demonstrated that morphine binds to an accessory protein of Toll-like receptor 4, myeloid differentiation protein 2 (MD-2), thereby inducing TLR4 oligomerization and triggering proinflammation, demonstrating that morphine-induced pro inflammation only depends onTLR4, despite the presence of opioid receptors.
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Pharmacogenetics of opioids.
TL;DR: The role of pharmacogenomics in mediating interpatient variability in efficacy and side effects to this important class of drugs will be better informed as knowledge regarding the interplay between genes affecting opioid pharmacokinetics including cerebral kinetics and pharmacodynamics increases.
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Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia
Mark R. Hutchinson,Benjamen D. Coats,Susannah S. Lewis,Yingning Zhang,David Sprunger,Niloofar Rezvani,Eric M. Baker,Brian M. Jekich,Julie Wieseler,Andrew A. Somogyi,David Martin,Stephen Poole,Charles M. Judd,Steven F. Maier,Linda R. Watkins +14 more
TL;DR: It is demonstrated that the action of several spinal proinflammatory cytokines oppose systemic and intrathecal opioid analgesia, causing reduced pain suppression and providing a novel mechanism for the opposition of acute opioid morphine analgesia.
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Hyperalgesic responses in methadone maintenance patients
TL;DR: Although responding to changes in plasma methadone concentration, maintenance patients are markedly hyperalgesic to pain induced by the cold pressor test, determined by the nature of the nociceptive stimulus.
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Reduction of metformin renal tubular secretion by cimetidine in man.
TL;DR: It is concluded that cimetidine inhibits the renal tubular secretion of met formin in man, resulting in higher circulating plasma concentrations, and the dose of metformin should be reduced when cimeidine is co-prescribed.