Institution
National Institute for Biological Standards and Control
Facility•Potters Bar, United Kingdom•
About: National Institute for Biological Standards and Control is a facility organization based out in Potters Bar, United Kingdom. It is known for research contribution in the topics: Virus & Antibody. The organization has 1674 authors who have published 3186 publications receiving 130923 citations.
Topics: Virus, Antibody, Antigen, Vaccination, Monoclonal antibody
Papers published on a yearly basis
Papers
More filters
••
TL;DR: It is suggested that the deoxyribose assay is a simple and cheap alternative to pulse radiolysis for determination of rate constants for reaction of most biological molecules with hydroxyl radicals.
2,296 citations
••
2,037 citations
••
[...]
TL;DR: This work has shown that mortality may be due to an energy-saving strategy of reduced error regulation in somatic cells, which supports Orgel's ‘error catastrophe’ hypothesis and offers a new basis for the study of normal and abnormal ageing syndromes and of apparently immortal transformed cell lines.
Abstract: An evolutionary view of ageing suggests that mortality may be due to an energy-saving strategy of reduced error regulation in somatic cells. This supports Orgel's ‘error catastrophe’ hypothesis and offers a new basis for the study of normal and abnormal ageing syndromes and of apparently immortal transformed cell lines.
1,513 citations
••
TL;DR: Prostaglandin E2 levels in the cerebrospinal fluid are Elevated by finding a widespread induction of Cox-2 expression in spinal cord neurons and in other regions of the CNS, and preventing central prostanoid production by inhibiting the interleukin-1β-mediated induction ofcox-2 in neurons reduces centrally generated inflammatory pain hypersensitivity.
Abstract: Inflammation causes the induction of cyclooxygenase-2 (Cox-2), leading to the release of prostanoids, which sensitize peripheral nociceptor terminals and produce localized pain hypersensitivity. Peripheral inflammation also generates pain hypersensitivity in neighbouring uninjured tissue (secondary hyperalgesia), because of increased neuronal excitability in the spinal cord (central sensitization), and a syndrome comprising diffuse muscle and joint pain, fever, lethargy and anorexia. Here we show that Cox-2 may be involved in these central nervous system (CNS) responses, by finding a widespread induction of Cox-2 expression in spinal cord neurons and in other regions of the CNS, elevating prostaglandin E2 (PGE2) levels in the cerebrospinal fluid. The major inducer of central Cox-2 upregulation is interleukin-1beta in the CNS, and as basal phospholipase A2 activity in the CNS does not change with peripheral inflammation, Cox-2 levels must regulate central prostanoid production. Intraspinal administration of an interleukin-converting enzyme or Cox-2 inhibitor decreases inflammation-induced central PGE2 levels and mechanical hyperalgesia. Thus, preventing central prostanoid production by inhibiting the interleukin-1beta-mediated induction of Cox-2 in neurons or by inhibiting central Cox-2 activity reduces centrally generated inflammatory pain hypersensitivity.
1,284 citations
••
TL;DR: Currently available assays for measuring peroxidation are reviewed--the more specific the assay used, the less peroxide is found in healthy human tissues and body fluids.
1,241 citations
Authors
Showing all 1676 results
Name | H-index | Papers | Citations |
---|---|---|---|
Barry Halliwell | 173 | 662 | 159518 |
Victor J. Dzau | 130 | 688 | 66047 |
Adrian Jenkins | 118 | 427 | 66331 |
Willem H. Ouwehand | 106 | 392 | 64572 |
Paul Williams | 106 | 398 | 35718 |
Nancy J. Rothwell | 102 | 444 | 37193 |
Ching-Lung Lai | 98 | 622 | 41930 |
Martin C. J. Maiden | 94 | 393 | 36732 |
Kingston H. G. Mills | 92 | 313 | 29630 |
Ulf Lindahl | 92 | 268 | 28407 |
Jacqueline M. Katz | 91 | 323 | 34111 |
Thomas B. L. Kirkwood | 81 | 342 | 27943 |
Martin F. Lavin | 79 | 456 | 26092 |
Mary Collins | 74 | 240 | 22691 |
John M.C. Gutteridge | 69 | 136 | 47994 |