Andrew F. Hill

TL;DR: This study provides the first detailed whole transcriptomic analysis of pathways involved in MPTP-induced Parkinsonism and identifies key therapeutic pathways targeted by a potentially new class of neuroprotective agents which may provide therapeutic benefits for other neurodegenerative disorders.

TL;DR: Data implicate a pathological role for tau in early Parkinson’s disease and initial primary cell culture experiments have demonstrated that ablation of tau results in the release of α-synuclein enriched exosomes, providing a potential mechanism for disease spread.

TL;DR: This study authenticates a subcellular disparity in PrPres and infectivity levels, and eliminates simultaneous divergence of prion strains as the explanation for this phenomenon, and align best with the concept that transmission efficiency is influenced more by intrinsic characteristics of the infectious prion, rather than cellular microenvironment conditions or absolute PrPres levels.

TL;DR: A one-touch integrated small RNA analysis pipeline (iSRAP) research tool that is composed of widely used tools for rapid profiling of small RNAs that offers comprehensive analysis of small RNA sequencing data that leverage informed decisions on the downstream analyses of smallRNA studies, including extracellular vesicles such as exosomes.

TL;DR: Modification of neuronal cholesterol trafficking and of lipid rafts by Nef may contribute to early stages of neurodegeneration and pathogenesis in HAND.