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Robyn A. Sharples
Researcher at University of Melbourne
Publications - 26
Citations - 3451
Robyn A. Sharples is an academic researcher from University of Melbourne. The author has contributed to research in topics: Amyloid precursor protein & Presenilin. The author has an hindex of 22, co-authored 26 publications receiving 2975 citations. Previous affiliations of Robyn A. Sharples include La Trobe University.
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Journal ArticleDOI
Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood
TL;DR: This study demonstrates thatExosomal RNA is protected by RNaseA treatment and that exosomes provide a consistent source of miRNA for disease biomarker detection.
Journal ArticleDOI
Packaging of prions into exosomes is associated with a novel pathway of PrP processing
Laura J Vella,Robyn A. Sharples,Victoria A. Lawson,C.L. Masters,Roberto Cappai,Andrew F. Hill +5 more
TL;DR: The data suggest that exosomes represent a potent pool of prion infectivity and provide a mechanism for studying prion spread and PrP processing in cells endogenously expressing PrP.
Journal ArticleDOI
Prognostic serum miRNA biomarkers associated with Alzheimer’s disease shows concordance with neuropsychological and neuroimaging assessment
Lesley Cheng,James D. Doecke,Robyn A. Sharples,Victor L. Villemagne,Chris Fowler,Alan Rembach,Ralph N. Martins,Christopher C. Rowe,S L Macaulay,Colin L. Masters,Andrew F. Hill +10 more
TL;DR: The data suggest that an exosomal miRNA signature may have potential to be developed as a suitable peripheral screening tool for AD.
Journal ArticleDOI
Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity.
Anthony R. White,Anthony R. White,Tai Du,Tai Du,Katrina M. Laughton,Irene Volitakis,Robyn A. Sharples,Michel E Xilinas,David E. Hoke,R. M. Damian Holsinger,Genevieve Evin,Robert A. Cherny,Andrew F. Hill,Kevin J. Barnham,Qiao-Xin Li,Ashley I. Bush,Colin L. Masters,Colin L. Masters +17 more
TL;DR: These findings identify an alternative mechanism of action for CQ in the reduction of Aβ deposition in the brains of CQ-treated animals and potentially in Alzheimer disease patients.
Journal ArticleDOI
Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway
Roberto Cappai,Su-Ling Leck,Deborah J. Tew,Deborah J. Tew,Nicholas A. Williamson,David Smith,David Smith,Denise Galatis,Denise Galatis,Robyn A. Sharples,Cyril C. Curtain,Cyril C. Curtain,Feda E. Ali,Feda E. Ali,Robert A. Cherny,Robert A. Cherny,Janetta G. Culvenor,Janetta G. Culvenor,Stephen P. Bottomley,Colin L. Masters,Colin L. Masters,Kevin J. Barnham,Kevin J. Barnham,Andrew F. Hill +23 more
TL;DR: DA inhibited the formation of iron‐induced α‐SN amyloidogenic aggregates, suggesting that DA acts as a dominant modulator of α‐ SN aggregation, and support the paradigm emerging for other neurodegenerative diseases that the toxic species is represented by a soluble oligomer and not the insoluble fibril.