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Andrew J. Burghardt
Researcher at University of California, San Francisco
Publications - 125
Citations - 8080
Andrew J. Burghardt is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Quantitative computed tomography & Bone mineral. The author has an hindex of 46, co-authored 120 publications receiving 7166 citations. Previous affiliations of Andrew J. Burghardt include University of California & University of California, Berkeley.
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Journal ArticleDOI
The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase
Attila Mócsai,Mary Beth Humphrey,Jessica Van Ziffle,Yongmei Hu,Andrew J. Burghardt,Steven C. Spusta,Sharmila Majumdar,Lewis L. Lanier,Clifford A. Lowell,Mary C. Nakamura +9 more
TL;DR: Data indicate that recruitment of Syk to phosphorylated ITAMs is critical for osteoclastogenesis, which provides new insight into the biology of osteoclasts and suggest novel therapeutic targets in diseases of bony remodeling.
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Reproducibility of direct quantitative measures of cortical bone microarchitecture of the distal radius and tibia by HR-pQCT ☆
TL;DR: It is indicated that HR-pQCT measures of cortical bone density and architecture can be measured in vivo with high reproducibility and limited bias across a biologically relevant range of values.
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High-Resolution Peripheral Quantitative Computed Tomographic Imaging of Cortical and Trabecular Bone Microarchitecture in Patients with Type 2 Diabetes Mellitus
Andrew J. Burghardt,Ahi Sema Issever,Ahi Sema Issever,Ann V. Schwartz,Kevin A. Davis,Umesh Masharani,Sharmila Majumdar,Thomas M. Link +7 more
TL;DR: The findings suggest that T2DM may be associated with impaired resistance to bending loads due to inefficient redistribution of bone mass, characterized by loss of intracortical bone offset by an elevation in trabecular bone density.
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Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures
Janina M. Patsch,Andrew J. Burghardt,Samuel P. Yap,Thomas Baum,Ann V. Schwartz,Gabby B. Joseph,Thomas M. Link +6 more
TL;DR: It is suggested that severe deficits in cortical bone quality are responsible for fragility fractures in postmenopausal diabetic women.
Journal ArticleDOI
Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia.
Andrew J. Burghardt,Galateia J. Kazakia,Sweta Ramachandran,Thomas M. Link,Sharmila Majumdar,Sharmila Majumdar +5 more
TL;DR: Age‐related differences in cortical porosity, as detected by HR‐pQCT, are more pronounced than differences in standard cortical metrics and the biomechanical significance of these structural differences increases with age for men and women and provides discriminatory information for menopause‐related bone quality effects.