M
Mary Beth Humphrey
Researcher at University of Oklahoma Health Sciences Center
Publications - 73
Citations - 6036
Mary Beth Humphrey is an academic researcher from University of Oklahoma Health Sciences Center. The author has contributed to research in topics: Osteoclast & Receptor. The author has an hindex of 39, co-authored 66 publications receiving 5030 citations. Previous affiliations of Mary Beth Humphrey include Baylor College of Medicine & University of Oklahoma.
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Journal ArticleDOI
The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase
Attila Mócsai,Mary Beth Humphrey,Jessica Van Ziffle,Yongmei Hu,Andrew J. Burghardt,Steven C. Spusta,Sharmila Majumdar,Lewis L. Lanier,Clifford A. Lowell,Mary C. Nakamura +9 more
TL;DR: Data indicate that recruitment of Syk to phosphorylated ITAMs is critical for osteoclastogenesis, which provides new insight into the biology of osteoclasts and suggest novel therapeutic targets in diseases of bony remodeling.
Journal ArticleDOI
Cutting Edge: Inhibition of TLR and FcR Responses in Macrophages by Triggering Receptor Expressed on Myeloid Cells (TREM)-2 and DAP12
Jessica A. Hamerman,Jessica Jarjoura,Mary Beth Humphrey,Mary C. Nakamura,William E. Seaman,Lewis L. Lanier +5 more
TL;DR: It is shown that Triggering Receptor Expressed on Myeloid cells (TREM)-2 is responsible for the DAP12-mediated inhibition in mouse macrophages and the interaction of TREM-2 and its ligand results in an inhibitory signal that can reduce the inflammatory response.
Journal ArticleDOI
2017 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis
Lenore Buckley,Gordon Guyatt,Howard A Fink,Michael Cannon,Jennifer M. Grossman,Karen E. Hansen,Mary Beth Humphrey,Nancy E Lane,Marina Magrey,Marc Miller,Lake Morrison,Madhumathi Rao,Angela Byun Robinson,Sumona Saha,Susan Wolver,Raveendhara R. Bannuru,Elizaveta E. Vaysbrot,Mikala C. Osani,Marat Turgunbaev,Amy S. Miller,Timothy E. McAlindon +20 more
TL;DR: To develop recommendations for prevention and treatment of glucocorticoid‐induced osteoporosis (GIOP).
Journal ArticleDOI
2017 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis: ACR GUIDELINE FOR GLUCOCORTICOID-INDUCED OSTEOPOROSIS PREVENTION AND TREATMENT
Lenore Buckley,Gordon H. Guyatt,Howard A Fink,Michael Cannon,Jennifer M. Grossman,Karen E. Hansen,Mary Beth Humphrey,Nancy E Lane,Marina Magrey,Marc L. Miller,Lake Morrison,Madhumathi Rao,Angela Byun Robinson,Sumona Saha,Susan Wolver,Raveendhara R. Bannuru,Elizaveta E. Vaysbrot,Mikala C. Osani,Marat Turgunbaev,Amy S. Miller,Timothy E. McAlindon +20 more
TL;DR: To develop recommendations for prevention and treatment of glucocorticoid‐induced osteoporosis (GIOP).
Journal ArticleDOI
TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.
Qisheng Peng,Qisheng Peng,Shikha Malhotra,James A. Torchia,William G. Kerr,K. Mark Coggeshall,Mary Beth Humphrey,Mary Beth Humphrey +7 more
TL;DR: A previously uncharacterized interaction of SHIP1 with DAP12 is demonstrated that functionally limits TREM2- and DAP 12-dependent signaling and a mechanism through which SHIP 1 regulates key ITAM-containing receptors by directly blocking the binding and activation of PI3K is identified.