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Andrew M. Kopelman
Researcher at Stanford University
Publications - 3
Citations - 1258
Andrew M. Kopelman is an academic researcher from Stanford University. The author has contributed to research in topics: Oncogene & Carcinogenesis. The author has an hindex of 3, co-authored 3 publications receiving 1158 citations.
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Journal ArticleDOI
MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
Catherine M. Shachaf,Andrew M. Kopelman,Constadina Arvanitis,Asa Karlsson,Shelly Beer,Stefanie Mandl,Michael Bachmann,Alexander D. Borowsky,Boris H. Ruebner,Robert D. Cardiff,Qiwei Yang,J. Michael Bishop,Christopher H. Contag,Dean W. Felsher +13 more
TL;DR: It is reported that inactivation of the MYC oncogene is sufficient to induce sustained regression of invasive liver cancers and how oncogenic inactivation may reverse tumorigenesis in the most clinically difficult cancers is shown.
Journal ArticleDOI
CD4+ T Cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene Inactivation
Kavya Rakhra,Pavan Bachireddy,Tahera Zabuawala,Robert Zeiser,Liwen Xu,Andrew M. Kopelman,Alice C. Fan,Qiwei Yang,Lior Z. Braunstein,Erika J. Crosby,Sandra Ryeom,Dean W. Felsher +11 more
TL;DR: CD4(+) T cells are required for the remodeling of the tumor microenvironment through the expression of chemokines, such as thrombospondins, in order to elicit oncogene addiction.
Journal ArticleDOI
Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch
Sylvie Giuriato,Sandra Ryeom,Alice C. Fan,Pavan Bachireddy,Ryan C. Lynch,Matthew J. Rioth,Jan van Riggelen,Andrew M. Kopelman,Emmanuelle Passegué,Emmanuelle Passegué,Flora Tang,Judah Folkman,Dean W. Felsher +12 more
TL;DR: It is reported here that the targeted inactivation of MYC is sufficient to induce sustained regression of hematopoietic tumors in transgenic mice, except in tumors that had lost p53 function and concluded that angiogenesis is an essential component of oncogene addiction.