Stefanie Mandl

TL;DR: It is reported that inactivation of the MYC oncogene is sufficient to induce sustained regression of invasive liver cancers and how oncogenic inactivation may reverse tumorigenesis in the most clinically difficult cancers is shown.

TL;DR: Animal models are important tools to investigate the pathogenesis and develop treatment strategies for bone metastases in humans and there are few spontaneous models of bone metastasis despite the fact that rodents and other animals often spontaneously develop cancer.

TL;DR: In vivo bioluminescence imaging is a rapid and noninvasive functional imaging method that employs light‐emitting reporters and external photon detection to follow biological processes in living animals in real time that enables the studies of trafficking patterns for a variety of cell types in live animal models of human biology and disease.

TL;DR: Multimodality imaging revealed the temporal patterns of tumor cell loss and annexin V uptake revealing a better understanding of the timing of radiolabeled annexinV uptake for its development as a marker of therapeutic efficacy.

TL;DR: Tc-HuS/Hu-VEGF complex is stable for at least 1 h in vivo and can be effectively used to image mouse tumor neovasculature in lesions as small as several millimeters in soft tissue.