A
Angela Fan
Publications - 1
Citations - 139
Angela Fan is an academic researcher. The author has contributed to research in topics: Cancer epigenetics & DNA repair. The author has an hindex of 1, co-authored 1 publications receiving 127 citations.
Papers
More filters
Journal ArticleDOI
Inhibition of histone deacetylase in cancer cells slows down replication forks, activates dormant origins, and induces DNA damage.
Chiara Conti,Elisabetta Leo,Gabriel S. Eichler,Olivier Sordet,Melvenia M. Martin,Angela Fan,Mirit I. Aladjem,Yves Pommier +7 more
TL;DR: It is found that pharmacologic concentrations of SAHA induce replication-mediated DNA damage with activation of histone gammaH2AX, establishing a critical link between robust chromatin acetylation and DNA replication in human cancer cells.