O
Olivier Sordet
Researcher at University of Toulouse
Publications - 52
Citations - 4735
Olivier Sordet is an academic researcher from University of Toulouse. The author has contributed to research in topics: Topoisomerase & Apoptosis. The author has an hindex of 33, co-authored 52 publications receiving 4373 citations. Previous affiliations of Olivier Sordet include Centre national de la recherche scientifique & National Institutes of Health.
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Journal ArticleDOI
Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks
TL;DR: This review will focus on programmed cell death (apoptosis) and on survival pathways (Bcl-2, Apaf-1, AKT, NF-κB) involved in multidrug resistance, and introduce the ‘permissive apoptosis-resistance’ model for the selection ofMultidrug-resistant cells.
Journal ArticleDOI
Specific involvement of caspases in the differentiation of monocytes into macrophages.
Olivier Sordet,Cédric Rébé,Cédric Rébé,Cédric Rébé,Stéphanie Plenchette,Stéphanie Plenchette,Stéphanie Plenchette,Yael Zermati,Yael Zermati,Yael Zermati,Olivier Hermine,Olivier Hermine,Olivier Hermine,William Vainchenker,William Vainchenker,William Vainchenker,Carmen Garrido,Carmen Garrido,Carmen Garrido,Eric Solary,Eric Solary,Eric Solary,Laurence Dubrez-Daloz,Laurence Dubrez-Daloz,Laurence Dubrez-Daloz +24 more
TL;DR: It is shown that several caspases are activated in human peripheral blood monocytes whose differentiation into macrophages is induced by macrophage colony-stimulating factor (M-CSF).
Journal ArticleDOI
Repair of and checkpoint response to topoisomerase I-mediated DNA damage.
Yves Pommier,Christophe E. Redon,V. Ashutosh Rao,Jennifer A. Seiler,Olivier Sordet,H. Takemura,Smitha Antony,Linghua Meng,Zhi-Yong Liao,Glenda Kohlhagen,Hongliang Zhang,Kurt W. Kohn +11 more
TL;DR: Defects in these repair/checkpoint pathways, which promote tumor development, explain the selectivity of camptothecins and other Top1 inhibitors for cancer cells.
Journal ArticleDOI
Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications.
Annamaria Rapisarda,Badarch Uranchimeg,Olivier Sordet,Yves Pommier,Robert H. Shoemaker,Giovanni Melillo +5 more
TL;DR: It is demonstrated that TPT does not affect Hif-1α protein half-life or mRNA accumulation but inhibits its translation, and the existence of a novel pathway connecting Top 1-dependent signaling events and the regulation of HIF-1 α protein expression and function is demonstrated.
Book ChapterDOI
Repair of topoisomerase I-mediated DNA damage.
Yves Pommier,Juana M. Barcelo,Juana M. Barcelo,V. Ashutosh Rao,V. Ashutosh Rao,Olivier Sordet,Olivier Sordet,Andrew Jobson,Andrew Jobson,Laurent Thibaut,Laurent Thibaut,Ze-Hong Miao,Ze-Hong Miao,Jennifer A. Seiler,Jennifer A. Seiler,Hongliang Zhang,Hongliang Zhang,Christophe Marchand,Christophe Marchand,Keli Agama,Keli Agama,John L. Nitiss,John L. Nitiss,Christophe E. Redon,Christophe E. Redon +24 more
TL;DR: This chapter reviews the developments in several pathways involved in the repair of Top1 cleavage complexes and the role of Chk1 and Chk2 checkpoint kinases in the cellular responses to Top1 inhibitors.