A
Angelo H. C. Chan
Publications - 3
Citations - 127
Angelo H. C. Chan is an academic researcher. The author has contributed to research in topics: Venom & Poison control. The author has an hindex of 2, co-authored 2 publications receiving 113 citations.
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Evolution stings: the origin and diversification of scorpion toxin peptide scaffolds.
Kartik Sunagar,Eivind A. B. Undheim,Angelo H. C. Chan,Ivan Koludarov,Sergio A. Muñoz-Gómez,Agostinho Antunes,Bryan G. Fry +6 more
TL;DR: It is demonstrated that even neglected lineages of scorpions are a rich pool of novel biochemical components, which have evolved over millions of years to target specific ion channels in prey animals, and as a result, possess tremendous implications in therapeutics.
Journal ArticleDOI
Venom down under: dynamic evolution of Australian elapid snake toxins.
Timothy N.W. Jackson,Kartik Sunagar,Eivind A. B. Undheim,Ivan Koludarov,Angelo H. C. Chan,Kate L. Sanders,Syed Abid Ali,Iwan Hendrikx,Nathan Dunstan,Bryan G. Fry +9 more
TL;DR: This study recovered the first full-length sequences for multimeric phospholipase A2 ‘taipoxin/paradoxin’ subunits from non-Oxyuranus species, confirming the early recruitment of this extremely potent neurotoxin complex to the venom arsenal of Australian elapid snakes.
Posted ContentDOI
Orphan C/D box snoRNAs modulate fear-related memory processes in mice
Laura J. Leighton,Qiongyi Zhao,Paul R. Marshall,Sachithrani U. Madugalle,Angelo H. C. Chan,Mason Musgrove,Haobin Ren,Ambika Periyakaruppiah,Janette Edson,Wei Wei,Robert C. Spitale,Timothy W. Bredy +11 more
TL;DR: A population of experience-dependent small nucleolar RNAs (snoRNAs) is discovered, and several of these are recruited to the synaptic compartment in response to fear extinction learning, including the orphan snoRNA snord64, which drives the methylation of the mRNA encoding the ubiquitin ligase, RNF146.