A
Angelo Rafael Carpinelli
Researcher at University of São Paulo
Publications - 118
Citations - 4511
Angelo Rafael Carpinelli is an academic researcher from University of São Paulo. The author has contributed to research in topics: Pancreatic islets & Insulin. The author has an hindex of 32, co-authored 114 publications receiving 4179 citations. Previous affiliations of Angelo Rafael Carpinelli include Free University of Brussels & Université libre de Bruxelles.
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Journal ArticleDOI
Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity.
Philip Newsholme,E. P. Haber,Sandro M. Hirabara,Eduardo Rebelato,Joaquim Procopio,D. Morgan,H. C. Oliveira-Emilio,Angelo Rafael Carpinelli,Rui Curi +8 more
TL;DR: NADPH oxidase associated ROS may be a useful target for intervention strategies based on reversing the negative impact of glucolipotoxicity in diabetes and may alter parameters of signal transduction, insulin secretion, insulin action and cell proliferation or cell death.
Journal ArticleDOI
Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line.
D. Morgan,H. R. Oliveira-Emilio,Declan Keane,Aparecida Emiko Hirata,M. Santos da Rocha,Silvana Bordin,Rui Curi,Philip Newsholme,Angelo Rafael Carpinelli +8 more
TL;DR: NADPH oxidase may play a key role in normal beta cell physiology, but under specific conditions may also contribute to beta cell demise.
Journal ArticleDOI
Pancreatic β-Cells Express Phagocyte-Like NAD(P)H Oxidase
H R. Oliveira,Rozangela Verlengia,Carla Roberta de Oliveira Carvalho,Luiz R.G. Britto,Rui Curi,Angelo Rafael Carpinelli +5 more
TL;DR: The involvement of protein kinase C (PKC) in the stimulatory effect of glucose was confirmed by incubation of islets with phorbol myristate acetate ( a PKC activator) and bysindoylmaleimide (GF109203X) (a PKC-specific inhibitor).
Pancreatic -Cells Express Phagocyte-Like NAD(P)H
TL;DR: The involvement of protein kinase C (PKC) in the stimulatory effect of glucose was confirmed by incubation of islets with phorbol myristate acetate (a PKC activator) and bysindoylmaleimide (GF109203X).
Journal ArticleDOI
Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell
Philip Newsholme,D. Morgan,Eduardo Rebelato,H. C. Oliveira-Emilio,Joaquim Procopio,Rui Curi,Angelo Rafael Carpinelli +6 more
TL;DR: Recent information and evidence of NADPH oxidase-dependent generation of ROS in pancreatic beta cells are described and the various beta cell isoforms may, via differences in the kinetics and species of ROS generated, positively and negatively regulate insulin secretion and cell survival are identified.