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Angie Stone
Researcher at National Center for Toxicological Research
Publications - 20
Citations - 1492
Angie Stone is an academic researcher from National Center for Toxicological Research. The author has contributed to research in topics: Genotype & Odds ratio. The author has an hindex of 18, co-authored 20 publications receiving 1449 citations. Previous affiliations of Angie Stone include University of Arkansas for Medical Sciences & United States Department of Veterans Affairs.
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Journal Article
Genetic Polymorphisms in Catechol-O-Methyltransferase, Menopausal Status, and Breast Cancer Risk
Patricia A. Thompson,Peter G. Shields,Jo L. Freudenheim,Angie Stone,John E. Vena,James R. Marshall,Saxon Graham,Rosemary Laughlin,Takuma Nemoto,Fred F. Kadlubar,Christine B. Ambrosone +10 more
TL;DR: The association of risk with at least one low-activity COMT(Met) allele was strongest among the heaviest premenopausal women and among the leanest post menopausal women, suggesting that COMT, mediated by body mass index, may be playing differential roles in human breast carcinogenesis, dependent upon menopausal status.
Journal Article
Polymorphisms in glutathione S-transferases (GSTM1 and GSTT1) and survival after treatment for breast cancer.
Christine B. Ambrosone,Carol Sweeney,Brian F. Coles,Patricia A. Thompson,Gail Y. McClure,Soheila Korourian,Manal Y. Fares,Angie Stone,Fred F. Kadlubar,Laura F. Hutchins +9 more
TL;DR: Interindividual differences in activity of enzymes that prevent therapy-generated reactive oxidant damage may have an important impact on disease recurrence and overall survival among 251 women who received treatment for incident, primary breast cancer.
Journal ArticleDOI
Association Between Sulfotransferase 1A1 Genotype and Survival of Breast Cancer Patients Receiving Tamoxifen Therapy
Susan Nowell,Carol Sweeney,Maria Winters,Angie Stone,Nicholas P. Lang,Laura F. Hutchins,Fred F. Kadlubar,Christine B. Ambrosone +7 more
TL;DR: Sulfation of 4-OH TAM provides a previously unanticipated benefit, possibly due to alterations in the bioavailability of the active metabolite or to undefined estrogen receptor-mediated events, and is suggested to affect the efficacy of tamoxifen therapy.
Journal ArticleDOI
Hyperhomocysteinemia following a methionine load in patients with non-insulin-dependent diabetes mellitus and macrovascular disease
TL;DR: It is concluded that hyperhomocysteinemia is associated with macrovascular disease in a significant proportion of patients with NIDDM, and this association may contribute to the increased frequency and accelerated clinical course of vascular disease in patients with diabetes mellitus.
Journal Article
Association between survival after treatment for breast cancer and glutathione S-transferase P1 Ile105Val polymorphism.
Carol Sweeney,Gail Y. McClure,Manal Y. Fares,Angie Stone,Brian F. Coles,Patricia A. Thompson,Soheila Korourian,Laura F. Hutchins,Fred F. Kadlubar,Christine B. Ambrosone +9 more
TL;DR: Women with the low-activity Val/Val genotype had better survival according to GSTP1 genotype among women treated for breast cancer, suggesting that Inherited metabolic variability may influence treatment outcomes.