Government•Washington D.C., District of Columbia, United States•
About: United States Department of Veterans Affairs is a(n) government organization based out in Washington D.C., District of Columbia, United States. It is known for research contribution in the topic(s): Population & Veterans Affairs. The organization has 61475 authors who have published 70990 publication(s) receiving 3291429 citation(s). The organization is also known as: VA & Veterans Affairs Department.
Abstract: After cycling crashes, orthopedic and neurologic complaints are often the focus of evaluation and management. However, the trauma sustained may not be limited to physical injury; psychological issues brought on by or comorbid with the crash also warrant treatment. In this original research, we evaluated the presence of fear or anxiety after cycling crashes and examined factors associated with this mechanism of injury through a survey. Post-crash fear or anxiety was associated with female gender, a history of depression, and greater crash severity. Few cyclists received treatment and most returned to cycling at their previous level, but the timeline varied.
Abstract: Background : Previous work has indicated that differences in neurocognitive functioning may predict the development of adverse post-traumatic neuropsychiatric sequelae (APNS). Such differences may be vulnerability factors or simply correlates of APNS-related symptoms. Longitudinal studies that measure neurocognitive functioning at the time of trauma are needed to determine whether such differences precede the development of APNS. Methods : Here, we present findings from a subsample of 666 ambulatory patients from the AURORA (A dvancing U nderstanding of R ec O very afteR traum A ) study. All patients presented to EDs after a motor vehicle collision (MVC). We examined associations of neurocognitive test performance shortly after MVC with peritraumatic symptoms in the ED and APNS (depression, post-traumatic stress, post-concussive symptoms, and pain) 2 weeks and 8 weeks later. Neurocognitive tests assessed processing speed, attention, verbal reasoning, memory, and social perception. Results : Distress in the ED was associated with poorer processing speed and short-term memory. Poorer short-term memory was also associated with depression at 2 weeks post-MVC, even after controlling for peritraumatic distress. Finally, higher vocabulary scores were associated with pain 2 weeks post-MVC. Limitations : Self-selection biases among those who present to the ED and enroll in the study limit generalizability. Also, it is not clear whether observed neurocognitive differences predate MVC exposure or arise in the immediate aftermath of MVC exposure. Conclusions : Our results suggest that processing speed and short-term memory may be useful predictors of trauma-related characteristics and the development of some APNS, making such measures clinically-relevant for identifying at-risk individuals.
Abstract: Selective serotonin reuptake inhibitors (SSRIs) have been the cornerstone for the treatment of depression, anxiety, obsessive-compulsive disorder, and panic disorder for a wide spectrum of age groups. Although the beneficial therapeutic properties are well recognized by the medical community, it also possesses many undesirable adverse effects with clinical manifestations. Some of the effects can be severe. This chapter highlights use of SSRIs, the mechanism of action, medication dosages, common drug to drug interactions, and recommendations on management of the oral and maxillofacial surgery patient on SSRIs.
Abstract: A retrospective, observational analysis of 47 patients with aquaporin-4 immunoglobulin G-positive neuromyelitis optica spectrum disorder (AQP4-IgG+ NMOSD) enrolled at the University of Utah healthcare system was conducted. Visual acuity, neurological disability, and pain medication use were compared in relapsing versus non-relapsing patients. The median observation period was 3.6 years (range: 0.0–11.4 years); the annual relapse rate was 0.1376 (95% confidence interval: 0.0874, 0.191). Relapsing patients (n = 14) exhibited diminished visual acuity, clinically meaningful worsening of neurological disability, and greater pain medication use than non-relapsing patients (n = 33). Therapies that reduce the risk of relapses should be considered when making treatment decisions.
TL;DR: The current state of the field of PTSD genomics focusing on the effect of sex is reviewed, providing an overview of difference in heritability of PTSD based on sex, how difference in gene regulation based onsex impacts the PTSD brain, and what is known about genomic regulation that is dysregulated in specific cell types in PTSD.
Abstract: While a definitive understanding of the molecular pathology of posttraumatic stress disorder (PTSD) is far from a current reality, it has become increasingly clear that many of the molecular effects of PTSD are sex specific. Women are twice as likely as men to develop PTSD after a traumatic event, and neurobiological evidence suggests that there are structural differences between the brains of males versus females with PTSD. Recent advances in genomic technologies have begun to shed light on the sex-specific molecular determinants of PTSD, which seem to be governed predominantly by dysfunction of GABAergic (gamma-aminobutyric acidergic) signaling and immune function. We review the current state of the field of PTSD genomics focusing on the effect of sex. We provide an overview of difference in heritability of PTSD based on sex, how difference in gene regulation based on sex impacts the PTSD brain, and what is known about genomic regulation that is dysregulated in specific cell types in PTSD.
Showing all 61475 results
|Robert J. Lefkowitz||214||860||147995|
|Irving L. Weissman||201||1141||172504|
|Ronald M. Evans||199||708||166722|
|Robert M. Califf||196||1561||167961|
|Eric J. Topol||193||1373||151025|
|Nicholas G. Martin||192||1770||161952|
|Stephen V. Faraone||188||1427||140298|
|Gordon B. Mills||187||1273||186451|
|Scott M. Grundy||187||841||231821|
|Paul G. Richardson||183||1533||155912|
|Dennis S. Charney||179||802||122408|
|Bruce M. Spiegelman||179||434||158009|
|Kenneth C. Anderson||178||1138||126072|
|Kenneth S. Kendler||177||1327||142251|
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