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Anica Dricu
Researcher at University of Medicine and Pharmacy of Craiova
Publications - 77
Citations - 1632
Anica Dricu is an academic researcher from University of Medicine and Pharmacy of Craiova. The author has contributed to research in topics: Receptor & Growth factor receptor. The author has an hindex of 23, co-authored 69 publications receiving 1439 citations. Previous affiliations of Anica Dricu include Karolinska Institutet & Karolinska University Hospital.
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Journal ArticleDOI
Mevalonic Acid Is Limiting for N-Linked Glycosylation and Translocation of the Insulin-like Growth Factor-1 Receptor to the Cell Surface EVIDENCE FOR A NEW LINK BETWEEN 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE AND CELL GROWTH
Magdalena Carlberg,Anica Dricu,Harald Blegen,Min Wang,Magnus Hjertman,Peter Zickert,Anders Höög,Olle Larsson +7 more
TL;DR: It was confirmed that inhibition of HMG-CoA reductase activity and N-linked glycosylation also depressed the expression of functional IGF-1R in other cell types (i.e. hepatoblastoma cells and colon cancer cells) and suggested that this mechanism is involved in MVA-regulated cell growth.
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Ionizing radiation activates IGF-1R triggering a cytoprotective signaling by interfering with Ku-DNA binding and by modulating Ku86 expression via a p38 kinase-dependent mechanism.
TL;DR: It is demonstrated for the first time that ionizing radiation activates IGF-1R and in U1810 NSCLC cells γ-radiation activates IGF -1R within 10 min, with a maximal activation effect 2 h post-irradiation.
Journal Article
Increased expression of insulin-like growth factor I receptor in malignant cells expressing aberrant p53: functional impact.
Leonard Girnita,Ada Girnita,Bertha Brodin,Yuntao Xie,Gunnar Nilsson,Anica Dricu,Joakim Lundeberg,Johan Wejde,Armando Bartolazzi,Klas G. Wiman,Olle Larsson +10 more
TL;DR: The results suggest that up-regulation of IGF-IR as a result of expression of aberrant p53 may be important for the growth and survival of malignant cells.
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Expression of insulin-like growth factor-1 receptor (IGF-1R) and p27Kip1 in melanocytic tumors: a potential regulatory role of IGF-1 pathway in distribution of p27Kip1 between different cyclins.
TL;DR: It is shown that progression from benign nevi to malignant melanoma is paralleled by an increased expression of IGF-1R and a down-regulation of the cyclin-dependent kinase inhibitor p27Kip1, which may be a mechanism for growth arrest and induction of apoptosis following interruption of the IGF- 1 pathway in melanoma cells.
Journal Article
Inhibition of N-linked glycosylation using tunicamycin causes cell death in malignant cells: role of down-regulation of the insulin-like growth factor 1 receptor in induction of apoptosis.
TL;DR: The data suggest strongly that N-linked glycosylation plays an important role in maintenance of viability of melanoma cells through regulating the translocation of IGF-I receptor to the cell surface.