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Anil Tiwari
Researcher at Post Graduate Institute of Medical Education and Research
Publications - 8
Citations - 144
Anil Tiwari is an academic researcher from Post Graduate Institute of Medical Education and Research. The author has contributed to research in topics: Extracellular matrix & Fibronectin. The author has an hindex of 5, co-authored 8 publications receiving 121 citations.
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Isothiocyanates: a class of bioactive metabolites with chemopreventive potential
Gaurav Kumar,Hardeep Singh Tuli,Sonam Mittal,Jitendra Kumar Shandilya,Anil Tiwari,Sardul Singh Sandhu +5 more
TL;DR: This extensive review covers various molecular aspects of the interactions of ITCs with their recognized cellular targets involved in cancer treatment in order to enhance anti-tumor outcome with decreased toxicity to patients.
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Targeting the fibronectin type III repeats in tenascin-C inhibits epithelial-mesenchymal transition in the context of posterior capsular opacification.
TL;DR: The data suggest that the TNfnIII 1-5 repeats play an important role in PCO pathology, and TN64 is proposed as a novel antifibrotic therapeutic candidate.
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Fibrotic remodeling of the extracellular matrix through a novel (engineered, dual-function) antibody reactive to a cryptic epitope on the N-terminal 30 kDa fragment of fibronectin.
Maryada Sharma,Anil Tiwari,Shweta Sharma,Preeti Bhoria,Vishali Gupta,Amod Gupta,Manni Luthra-Guptasarma +6 more
TL;DR: The ability of this antibody to effectively reduce some of the hallmark features of fibrosis - migration, adhesion, fibronectin polymerization, matrix metalloprotease (MMP) expression, as well as reduction of collagen gel contraction in a model of fibrotic tissue remodeling is demonstrated.
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Control of fibrotic changes through the synergistic effects of anti-fibronectin antibody and an RGDS-tagged form of the same antibody.
TL;DR: An anti-fibrotic strategy using a combination of two antibodies: Fn52 (targeted against the N-terminal 30 kDa region of fibronectin, a major site for Fn self-association), and its engineered form, Fn52RGDS (which binds to integrins).
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Amelioration of collagen antibody induced arthritis in mice by an antibody directed against the fibronectin type III repeats of tenascin-C: Targeting fibronectin type III repeats of tenascin-C in rheumatoid arthritis
Brij Bhushan Mehta,Anil Tiwari,Saniya Sharma,Ashu Shukla,Maryada Sharma,Rakesh Kumar Vasishta,Ramesh Kumar Sen,Aman Sharma,Manni Luthra-Guptasarma +8 more
TL;DR: The data shows the efficacy of TN64 in preventing induction of arthritis, with significant downregulation of RA‐associated cytokines, suggests that components of the extracellular matrix such as the TNfnIII 1–5 region of TN‐C could be exploited to develop therapies to suppress inflammation seen in RA.