Ann S. Hashimoto

TL;DR: The results establish Sel K as an endoplasmic reticulum-membrane protein important for promoting effective Ca2+ flux during immune cell activation and provide insight into molecular mechanisms by which dietary selenium enhances immune responses.

TL;DR: The main response of the selenoproteome during hypertrophy does not involve increased GPX1, but increased GPx3 for reducing extracellular H( 2)O(2) and increasedGPx4, Trxrd1, and MsrB1 for minimizing intracellular oxidative damage.

TL;DR: It is found that calpain levels did not differ between intestinal tissues from inflammatory bowel disease (IBD) patients and healthy controls, but IBD tissues showed increased levels of the endogenous calpain inhibitor, calpastatin (CAST).

TL;DR: Overall, these findings suggest that intervention with a calpain-2 inhibitor may reduce colitis and colitis-associated cancer through a two-hit process of limiting macrophage activation and inhibiting growth of the colorectal cancer cells themselves.

TL;DR: Five human colon cancer cell lines were directly treated with a calpain‐2 inhibitor and results showed increased cell death in 4 of 5 cell lines and decreased anchorage‐independent growth for all cell five lines, suggesting calpain-2 inhibitor treatment may be most effective on colorectal tumors expressing highest levels of calpain•2.