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Nobuhisa Iwata
Researcher at Nagasaki University
Publications - 119
Citations - 12946
Nobuhisa Iwata is an academic researcher from Nagasaki University. The author has contributed to research in topics: Neprilysin & Amyloid precursor protein. The author has an hindex of 47, co-authored 116 publications receiving 11451 citations. Previous affiliations of Nobuhisa Iwata include Laboratory of Molecular Biology & Tokyo Metropolitan University.
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Journal ArticleDOI
Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
Yasumasa Yoshiyama,Makoto Higuchi,Bin Zhang,Shu-Ming Huang,Nobuhisa Iwata,Takaomi C. Saido,Jun Maeda,Tetsuya Suhara,John Q. Trojanowski,Virginia M.-Y. Lee +9 more
TL;DR: In this paper, the authors studied wild-type and P301S mutant human tau transgenic (Tg) mice and found that tangle formation was preceded by microglial activation.
Journal ArticleDOI
Metabolic Regulation of Brain Aβ by Neprilysin
Nobuhisa Iwata,Satoshi Tsubuki,Yoshie Takaki,Keiro Shirotani,Bao Lu,Norma P. Gerard,Craig Gerard,Emi Hama,Hahn-Jun Lee,Takaomi C. Saido +9 more
TL;DR: Observations suggest that even partial down-regulation of neprilysin activity, which could be caused by aging, can contribute to AD development by promoting Aβ accumulation.
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Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition.
Nobuhisa Iwata,Satoshi Tsubuki,Yoshie Takaki,Kaori Watanabe,Misaki Sekiguchi,Emi Hosoki,Maho Kawashima-Morishima,Hahn-Jun Lee,Emi Hama,Yoko Sekine-Aizawa,Takaomi C. Saido +10 more
TL;DR: This NEP-catalyzed proteolysis limits the rate of Aβ42 catabolism, up-regulation of which could reduce the risk of developing Alzheimer's disease by preventing Aβ accumulation.
Journal ArticleDOI
Single App knock-in mouse models of Alzheimer's disease
Takashi Saito,Yukio Matsuba,Naomi Mihira,Jiro Takano,Per Nilsson,Shigeyoshi Itohara,Nobuhisa Iwata,Takaomi C. Saido +7 more
TL;DR: In this paper, the authors generated knock-in mice that harbor Swedish and Beyreuther/Iberian mutations with and without the Arctic mutation in the APP gene, and the mice showed typical Aβ pathology, neuroinflammation and memory impairment in an age-dependent manner.
Journal ArticleDOI
Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls
Masahiro Maruyama,Hitoshi Shimada,Tetsuya Suhara,Hitoshi Shinotoh,Bin Ji,Jun Maeda,Ming-Rong Zhang,John Q. Trojanowski,Virginia M.-Y. Lee,Maiko Ono,Kazuto Masamoto,Harumasa Takano,Naruhiko Sahara,Naruhiko Sahara,Nobuhisa Iwata,Nobuyuki Okamura,Shozo Furumoto,Yukitsuka Kudo,Qing Chang,Takaomi C. Saido,Akihiko Takashima,Jada Lewis,Ming Kuei Jang,Ichio Aoki,Hiroshi Ito,Makoto Higuchi +25 more
TL;DR: A class of tau ligands, phenyl/pyridinyl-butadienyl-benzothiazoles/benZothiazoliums (PBBs), for visualizing diverse tau inclusions in brains of living patients with AD or non-AD tauopathies and animal models of these disorders are developed.