Anna A. Shtro

TL;DR: It is demonstrated that influenza viruses can be inhibited by adamantyl-azoles and thus have potential for developing antiviral agents with an alternate mechanism of action.

TL;DR: In this article, the antiviral activity of usnic acid and its derivatives against the pandemic influenza virus A(H1N1)pdm09 was studied for the first time, and a total of 26 compounds representing (+) and (-) isomers of usnik acid and their derivates were tested for cytotoxicity and anti-viral activity in MDCK cells by microtetrazolium test and virus yield assay, respectively.

TL;DR: Anti-influenza activity of camphor derivative 1,7,7-trimethylbicyclo (camphecene) is reported, showing the compound appeared the most effective when added at the early stages of viral life cycle and in direct hemagglutinin inhibition tests camphecenes was shown to decrease the activity of HA's of influenza viruses A and B.

TL;DR: It is revealed that (-)-usnic acid exhibited higher antiviral activity than its (+)-enantiomer, but in the pairs of enantiomer derivatives such as enamines, pyrazoles and chalcones, the (+-enantiomers were more potent inhibitors of the virus.

TL;DR: The design and synthesis of a series of novel heterocyclic derivatives of (–)-borneol and (–-isoborneol as potent inhibitors of the influenza A virus are presented.